月经周期不同阶段游离皮质醇昼夜节律的变化(英文)  

Changes in diurnal rhythms of free cortisol secretion during different phases of menstrual cycle

作　　者：包爱民[1] 刘荣玉[2] Eus J.W.VanSomeren Michel A.Hofman 周江宁[1] 

机构地区：[1]中国科学技术大学生命科学学院神经生物学系,合肥230032 [2]安徽医科大学第一附属医院安徽省老年病研究所,合肥230022 [3]Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO,The Netherlands

出　　处：《生理学报》2003年第5期547-553,共7页Acta Physiologica Sinica

基　　金：This work was supported by National Nature Science Foundation of China C030313 and KNAW 01CDP019. E. V. S was supported by NIBR Amsterdam, ZON-MW The Hague (project 28-3003), NWO The Hague (projects SOW 014-90-001 and Vernieuwingsimpuls), Stichting Centr

摘　　要：为了研究皮质醇分泌的昼夜节律在月经周期中的变化,实验对15位月经周期正常的育龄期健康妇女,在月经周期的不同阶段分别于24h内每隔两小时采样,检测唾液昼夜游离皮质醇水平。采用非线性回归分析模型分析皮质醇昼夜节律。结果显示,皮质醇昼夜节律在整个月经周期都具有复杂的明显受到亚节律(ultradian)影响的分泌形式;与月经期相比,围排卵期和黄体晚期昼夜节律波峰宽度(peak-width)明显减低(P=0.005与 0.031),而昼夜节律波谷(trough)有抬高趋势(P=0.0622与0.066);黄体晚期的亚节律波幅(ultradian amplitude)与月经期相比显著减低(P=0.002)而与围排卵期相比有减低趋势(P= 0.05)。这些结果提示月经周期的不同阶段对皮质醇分泌的昼夜节律有影响。The effect of the menstrual cycle on the diurnal cortisol rhythm was investigated in 15 normally cyclic healthywomen during reproductive life. Salivary cortisol was measured by radioimmunoassay in samples collected every 2 h for 24 hduring the four phases of the menstrual cycle: menstrual phase, late follicular/peri -ovulation phase, early to mid luteal phaseand late luteal phase, respectively. Distinct diurnal rhythms of free cortisol were found throughout the menstrual cycle by usinga nonlinear periodic regression model. The model was characterized by an asymmetrically peaked diurnal cycle and ultradianharmonics. There was a trend to higher troughs and significantly shorter peak-width in phase Ⅱ and phase Ⅳ compared tophase Ⅰ. The ultradian amplitude in phase Ⅳ was significantly lower compared with phase Ⅰ and showed a trend of decreasecompared with phase Ⅱ. The results suggest that the daily cortisol secretion is modulated by the phase of the menstrual cycle.

关 键 词：昼夜节律 亚节律 游离皮质醇 月经周期 唾液 

分 类 号：R33[医药卫生—人体生理学]