复方鳖甲方对肺纤维化大鼠高分辨率CT影响的实验研究  

Experimental Study on the Effects of Compound Biejia Formula on HRCT Images in the Rat Model of Pulmonary Fibrosis

作　　者：张东伟[1] 王继峰[1] 牛建昭[1] 金焕[1] 高宝华[1] 李贡宇[1] 

机构地区：[1]北京中医药大学细胞与生化实验室,北京100029

出　　处：《北京中医药大学学报》2003年第5期26-30,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目 (No .3 0 13 0 2 2 0 );教育部首批非典科技攻关项目

摘　　要：目的　研究复方鳖甲方对盐酸博莱霉素致大鼠肺纤维化的治疗作用。方法　SD雄性大鼠 5 4只 ,其中 4 5只经气管滴注盐酸博莱霉素 ,9只经气管滴注等体积的生理盐水 ,于 80d后平行观察大鼠高分辨率CT(HRCT)征象 ,行HRCT—病理对照研究。结果　肺纤维化大鼠HRCT可见肺实变 ,肺小叶间隔、间质不同程度地增厚及小叶结构变形 ,结节影 ,血管支气管束异常 ,胸膜增厚 ,交界面不规则 ,磨玻璃样密度影等 ,部分可见蜂窝肺。病理切片对照显示 ,肺组织纤维性增生 ,肺间质出现明显纤维化。复方鳖甲方能改善肺纤维化大鼠的HRCT影像 ,降低肺组织纤维性病变。Objective To study the effects of Compound Biejia Formula (CBF) on HRCT images in the rat model of pulmonary fibrosis induced by bleomycin. Methods 54 SD male rats were involved in this experiment. 45 Rats were given bleomycin by drip via the trachea and 9 rats were given the same dose of normal saline in the same way. After 80 days of the administration, HRCT images were observed in parallel in the two groups of the animals and at the same time, a HRCT pathological comparative study was carried out. Results It was found by HRCT that in the lung of the model rats, there was consolidation, thickened lobular septa and interstitium, lobular deformity, nodular shadows, bronchiovascular abnormality, thickened pleurae, ground glass like opacity, and even honeycomb lung in some animals; pathological slices showed that there was fibroid proliferation and marked fibrosis of the interstitium. CBF could improve HRCT images of the lung in the model rats and reduce pulmonary fibroid change. Conclusion The curative effects of CBF on the rats with pulmonary fibrosis may be related with its influencing the pulmonary structure.

关 键 词：复方鳖甲方 肺纤维化 高分辨率CT 大鼠 

分 类 号：R285.5[医药卫生—中药学]