褐藻酸性寡糖对帕金森病大鼠纹状体、杏仁核多巴胺释放的影响  

Effects of marine acidic oligose on dopamine release from stria- turn and amygdala in the rat models of Parkinson's disease

作　　者：董晓莉[1] 耿美玉[2] 管华诗[2] 谢俊霞[1] 

机构地区：[1]青岛大学医学院生理学教研室,山东青岛266021 [2]中国海洋大学药物与食品研究所,山东青岛266003

出　　处：《中国海洋药物》2003年第5期9-12,共4页Chinese Journal of Marine Drugs

基　　金：山东省自然科学基金(项目编号:L2000C01);省教育厅重点资助项目(项目编号:J01K03)

摘　　要：采用快速周期伏安法(FCV),在以6-羟基多巴胺(6-OHDA)制备的帕金森病(PD)模型大鼠上检测褐藻酸性寡糖HSH971对纹状体(Str)、杏仁核(Amy)多巴胺(DA)释放的影响。结果显示,腹腔注射HSH971 5mg·kg·d^(-1),7d能明显提高PD大鼠损毁侧Str、Amy的DA释放量,而对其健侧无影响。Fast cyclic voltammetry (FCV) was used to investigate the effects of marine acidic oligose HSH971 on dopamine (DA) release from striatum (Str) and amygdala (Amy) in 6-hydroxydopamine (6-OHDA) induced rat models of Parkinson's disease (PD). Results showed that HSH971 treated intraperitoneally at a dose of 5mg · kg · d-1 for 7 days increased DA release from the lesioned side of Str and Amy in PD rats, but DA release from the unle-sioned side has no change.

关 键 词：褐藻酸性寡糖HSH971 帕金森病 大鼠 多巴胺 快速周期伏安法 

分 类 号：R971[医药卫生—药品]