海藻酸钙凝胶微球的制备和pH依赖性溶胀  

Preparation and pH-Sensitive Reswelling of Calcium Alginate Gel Beads

作　　者：马萍[1] 祝力[2] 孙淑英[2] 梁冬梅[1] 

机构地区：[1]第二炮兵总医院药剂科,北京100088 [2]沈阳药科大学药学院,辽宁沈阳100016

出　　处：《中国海洋药物》2003年第5期35-37,共3页Chinese Journal of Marine Drugs

摘　　要：利用海藻酸钠溶液与氯化钙溶液发生胶凝反应,本文用滴制的方法制备了海藻酸钙凝胶微球,并对制备的处方和工艺进行了探讨,同时考察了海藻酸钙凝胶微球的特征和溶胀特性。干燥的凝胶微球在不同pH的水性介质中溶胀特性不同。海藻酸钙凝胶微球的这种溶胀的pH敏感性,使其能成为口服药物缓释制剂的载体。Ca-alginate gel beads were prepared by dropping Na-alginate solution into CaC2 solution; It's formulation and technology were discussed. At the same time, character and swelling property of Ca-alginate gel beads were studied. It should be note here that no swelling was observed in distilled water and 0. 1 mol· L-1 HCl(pH 1. 0) solution, while in phosphate buffer (pH6. 8) the dried beads swelled up to a diameter about 180% of its original diameter. Such a pH-sensitive swelling property could be advantageous for controlled release of orally-administered drug vehicles.

关 键 词：海藻酸钙凝胶微球 胶凝速率 溶胀特性 缓释 

分 类 号：R931.711[医药卫生—生药学] R943.4[医药卫生—药学]