复方红景天对肝纤维化模型大鼠血清中TNFα、TGFβ_1和IL-6的作用  

The effects of Compound Rhodiolas Sachalinensis A Bor on the serum levels of TNFα、TNFβ_1 and IL-6 in liver fibrosis rats

作　　者：曾维政[1] 吴晓玲[2] 蒋明德[1] 邓桂英[3] 熊碧君[1] 陈晓斌[1] 秦建平[1] 陈陵[1] 

机构地区：[1]成都军区总医院,四川成都610083 [2]重庆医科大学,257信箱重庆410016 [3]成都市第六人民医院,四川成都610051

出　　处：《华西药学杂志》2003年第4期260-262,共3页West China Journal of Pharmaceutical Sciences

基　　金：成都军区"十五"医药卫生科研基础课题 (0 1A0 0 9)

摘　　要：目的　探讨中药复方红景天对CCl4 诱导肝纤维化模型大鼠血清中TNFα、TGFβ1与IL - 6水平的影响。方法　雄性SD大鼠以CCl4 造模 ,并ig复方红景天。血清中肿瘤坏死因子α(TNFα)、转化生长因子β1(TGFβ1)、白介素 6 (IL - 6 )测定采用ELISA法 ,组织切片采用HE染色、VG和Masson染色。结果　治疗组TNFα、TGFβ1和IL - 6血清水平与未给予复方红景天组比较均存在非常显著的差异 (P <0 .0 0 1)。 3种细胞因子水平与肝组织切片的肝纤维化积分呈现良好的相关性。结论　复方红景天能显著降低肝纤维化模型大鼠血清中TNFα、TGFβ1与IL - 6水平 ,抑制肝组织纤维化形成。OBJECTIVE To study the protective effects of the traditional Chinese medicine Compound Rhodiolas Sanhalinensis A Bor(CRSAB) on CCl 4-induced liver fibrosis in rats.METHODS Male rats were given 30% CCl 4(3 ml·kg -1,twice a week for 14 weeks), and simultaneously treated with CRSAB (0.5 g·kg -1·d -1). The samples of liver were given histopathological examination. RESULTS The levels of serum TNFα、TGFβ 1 and IL-6 were lower in the CRSAB-treated rats than those in the CRSAB-untreated ones, and so were the degrees of fibrogenesis in liver tissues. CONCLUSION CRSAB can decrease significantly the levels of serum TNFα、TGFβ 1 and IL-6 in liver fibrosis model rats and inhibit fibrogenesis in liver tissue.

关 键 词：复方红景天 肝纤维化 肿瘤坏死因子α 转化生长因子βl 白细胞介素-6 

分 类 号：R259.75[医药卫生—中西医结合]