白背叶根对过氧化氢所致大鼠肝细胞损伤的保护作用  

Protective effects of the root of Mallotus apelta(Lour.)Muell.-Arg. on rat hepatocytes injury induced by hydrogen peroxide in vitro

作　　者：赵进军[1] 吕志平[1] 张绪富[1] 

机构地区：[1]第一军医大学中医系,广东广州510515

出　　处：《华西药学杂志》2003年第4期257-259,共3页West China Journal of Pharmaceutical Sciences

基　　金：全军医药卫生科研基金课题资助项目 (编号 :2 0 0 0B0 1)

摘　　要：目的　探讨中药白背叶根对过氧化氢 (H2 O2 )所致大鼠肝细胞损伤的影响。方法　用终浓度为 2mmol·L-1的H2 O2 对大鼠肝细胞进行损伤 ,收集肝细胞悬液 ,测定丙氨酸转氨酶 (ALT)、丙二醛 (MDA)、超氧化物歧化酶 (SOD)和一氧化氮 (NO)的含量。结果　白背叶根作用肝细胞后 ,能显著降低H2 O2 引起的NO和MDA水平的升高 ,并提高SOD活性 ,显著降低肝细胞悬液中ALT的浓度。结论　白背叶根对H2 O2 所致的大鼠肝细胞氧化损伤有保护作用。OBJECTIVE To investigate the effects of the root of Mallotus apelta(Lour.)Muell.-Arg. on rat hepatocytes injury induced by hydrogen peroxide (H 2O 2).METHODS Rat hepatocytes were prepared. H 2O 2 was added into the suspension till the final concentration was 2 mmol·L -1. SOD activity, NO and MDA contents, ALT level were detected. RESULTS The contents of NO and MDA were significantly decreased. The activity of SOD was increased. The elevated ALT level in the suspension induced by H 2O 2 was reduced. CONCLUSION The root of Mallotus apelta(Lour.)Muell.-Arg could protect hepatocytes from oxidative injury induced by H 2O 2.

关 键 词：白背叶根 中药 过氧化氢 肝细胞损伤 氧化损伤 

分 类 号：R259.75[医药卫生—中西医结合]