5-HT_(1A)受体激动剂类抗抑郁药的研究与开发  

Research and Development of 5-HT_(1A) Receptor Agonists, a New Class of Antidepressants

作　　者：陈芳萍[1] 李运曼[1] 刘国卿[1] 

机构地区：[1]中国药科大学药理教研室,江苏南京210009

出　　处：《药学进展》2003年第4期213-216,共4页Progress in Pharmaceutical Sciences

摘　　要：综述5-HT1A-受体激动剂抗抑郁作用的机制及其新产品的研究与开发。5-HT1A受体激动剂通过激动突触后膜 的5-HT1A受体,负反馈抑制海马5-HT能神经元上的自主受体而发挥抗抑郁作用,克服了传统抗抑郁药的滞后效应。5-HT1Aagonists, getting over the lagging effect of traditional antidepressants, act as antidepres-sants by exciting 5-HT1A receptors and inhibiting presynaptic 5-HT1A autoreceptors through negative feedback. In this paper, the acting mechanism and development of this class of antidepressants were highlighted.

关 键 词：5-HT1A受体激动剂 抗抑郁药 作用机制 氟斑色林 Vilazodone SLV-308 

分 类 号：R971.4[医药卫生—药品]