Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients  

作　　者：Wan-Fu Zhu Li-Min Yin Peng Li Jian Huang Hui Zhuang, Department of Microbiology, School of Basic Medical Sciences, Peking University, Beijing 100083, China 

出　　处：《World Journal of Gastroenterology》2003年第8期1739-1742,共4页世界胃肠病学杂志（英文版）

基　　金：the National Natural Science Foundation of China,No.39870695

摘　　要：AIM: To determine the pathogenicity of GB virus C (GBV-C)on liver and the effects of its co-infection on the clinical features and prognosis of patients with hepatitis B and C.METHODS: Cross-sectional study was carried out in 413patients with acute, chronic hepatitis B or liver cirrhosis,and in 67 hemodialysis patients. A 20-month prospective cohort study was carried out in 95 hepatitis B and 80 hepatitis C patients. A reverse transcriptase nested polymerase chain reaction (RT-nPCR) of the 5′-noncoding region was used to detect circulating GBV-C RNA. Liver function was determined by an automated analyzer for all patients.RESULTS: The prevalence of GBV-C in the high-risk populations with the virus transmitted via blood was high,ranging from 16.2 to 28.8%. Co-infection with GBV-C in hepatitis B patients did not affect the clinical features of the disease or liver function. The dialysis patients infected with GBV-C alone did not develop functional changes to the liver.Prospective cohort study showed that GBV-C co-infection did not affect the clinical features, prognosis or negative serum conversion rate of chronic hepatitis B and C.CONCLUSION: The results suggest that GBV-C has no marked pathogenicity on liver, so it may not be a hepatitis virus.AIM: To determine the pathogenicity of GB virus C (GBV-C) on liver and the effects of its co-infection on the clinical features and prognosis of patients with hepatitis B and C.METHODS: Cross-sectional study was carried out in 413 patients with acute, chronic hepatitis B or liver cirrhosis, and in 67 hemodialysis patients. A 20-month prospective cohort study was carried out in 95 hepatitis B and 80 hepatitis C patients. A reverse transcriptase nested polymerase chain reaction (RT-nPCR) of the 5’-noncoding region was used to detect circulating GBV-C RNA. Liver function was determined by an automated analyzer for all patients.RESULTS: The prevalence of GBV-C in the high-risk populations with the virus transmitted via blood was high, ranging from 16.2% to 28.8%. Co-infection with GBV-C in hepatitis B patients did not affect the clinical features of the disease or liver function. The dialysis patients infected with GBV-C alone did not develop functional changes to the liver. Prospective cohort study showed that GBV-C co-infection did not affect the clinical features, prognosis or negative serum conversion rate of chronic hepatitis B and C.CONCLUSION: The results suggest that GBV-C has no marked pathogenicity on liver, so it may not be a hepatitis virus.

关 键 词：病毒性肝炎 血液透析 GB病毒 病原学 

分 类 号：R512.6[医药卫生—内科学] R459.5[医药卫生—临床医学]