多环芳烃接触者生物膜损伤指标的调查研究  

Investigating the biomembrane injury in workers exposed to polycyclic aromatic hydrocarbons(PAHs)

作　　者：张太江[1] 马永志[1] 肖文[1] 张俊萍[1] 王诗斌[2] 张巧[3] 

机构地区：[1]河南安阳市职业病防治所,安阳455000 [2]安阳钢铁公司安环部工业卫生科 [3]郑州大学公共卫生学院

出　　处：《广西预防医学》2003年第4期201-204,共4页Guangxi Journal of Preventive Medicine

摘　　要：目的了解多环芳烃接触者体内生物膜损伤情况 ,为劳动保护提供科学依据。方法对多环芳烃接触者55名 (接触组 )、正常对照人群40名 (对照组 )血清中丙二醛 (MDA)、超氧化物歧化酶总量 (T-SOD)、血清唾液酶 (SA)进行测定。结果接触组血清MDA、SA含量显著高于正常对照组 (P<0.001) ;血清T-SOD含量显著低于正常对照组 (P<0.001)。另外 ,对焦炉工按年龄、工龄和吸烟与否分别进行再分组分析 ,各指标差异均无显著性 (P>0.05)。结论多环芳烃职业接触者在临床症状出现前 。Objective To comprehend the human biomembrane injury in workers exposed to polycyclic aromatic hydrocarbons(PAHs)in order to protect the workers.Methods55workers(exposure group)and40controls(control group)were studied by measuring the levels of malondiˉaldehyde(MDA),total superoxide dismutase(T_SOD)and salicylic acid(SA)in surem.Results Serum MDA and SA concentration in exposure group is much higher than that of control group(P<0.001);serum T_SOD concentration is lower than that of control group(P<0.001);No significant difference between ages,working years and smokers or nonsmokers was found(P>0.05).Conclusion The results indicate the biomembranes injury induced by polycyclic aromatic hydrocarbons.

关 键 词：多环芳烃 职业接触者 生物膜损伤指标 血清丙二醛 血清唾液酶 超氧化物歧化酶 PAHS 煤焦沥青 SOD MDA SA CTP LPO 细胞不饱和酸脂质过氧化 

分 类 号：R136.32[医药卫生—劳动卫生] R135[医药卫生—公共卫生与预防医学]