慢性乙型肝炎HBV BCP变异157例的临床分析  

Clinical analysis of 157 chronic hepatitis B with HBV BCP mutation.

作　　者：任小华[1] 唐凌[1] 邵泽勇[1] 

机构地区：[1]泸州医学院附属医院,四川泸州646000

出　　处：《四川医学》2003年第9期882-883,共2页Sichuan Medical Journal

摘　　要：目的　探讨乙型肝炎病毒 (HBV)基因组基本核心区启动子 (basiccorepromoter ,BCP)变异的临床意义。方法　用微板杂交法和酶联免疫吸附试验联合检测HBVBCP变异 ,根据检测结果将HBV病毒血症患者分成变异阳性组(positive ,P)和变异阴性组 (negative ,N) ,比较分析两组患者的临床资料以评定BCP变异的意义。结果　 15 7例血清HBV DNA阳性的患者中检出BCP变异 67例 ,检出率 42 68% ,其中HBeAg(+ )者变异率略低于HBeAg(-)者 ,但无统计学意义。P、N组间性别、年龄、病程比较无显著差异 (P >0 0 5 )。肝功方面 ,HBeAg(+ )者 ,P、N组患者无差别 ,HBeAg(-)者P组ALT、AST水平显著高于N组 ,亦显著高于P组 ,HBeAg(+ )者 (P <0 0 1或 <0 0 5 )。结论　HBVBCP变异较普遍存在 ,但更多见于HBeAg(-)患者。变异对病情的影响与HBeAg有关 ,HBeAg( )者肝损害程度重于HBeAg(+ )Objective To investigate the clinical significance of hepatitis B virus basic core promoter(HBV BCP) mutation. Methods Micro-well liquid hybridization combined with enzyme linked immunosorbent assay(ELISA) were adopted to detect HBV BCP mutation. HBV viremia patients were divided into two groups according to the detection results:mutant positive group(P) and mutant negative group(N). Clinical data of both groups were analyzed and compared. Results Among 157 HBV patients,67 were confirmed to be HBV BCP mutant positive. In HBeAg(+)patients the mutation percentage is 39.78%(37/93),while in HBeAg(-)is 46.9(30/64). There were no significant differences between group P and N in term of age,sex and duration of disease(P>0.05). In HBeAg(+)patients,serum ALT、AST levels differed slightly between group P and N,while in HBeAg (-)patients,serum ALT、AST levels of group P were much higher than that of group N(P<0.01),and were much higher than HBeAg(+)patients of group P(P<0.01 or<0.05). Conclusion HBV BCP mutation is much popular in HBeAg(-) patients than that in HBeAg(+) ones but the difference is not significant. BCP mutation affect clinical situation via HBeAg pathway. HBeAg(-) Patients suffer from a more severe liver lesion than HBeAg(+) patients do.

关 键 词：乙型肝炎病毒 基因 变异 

分 类 号：R512.62[医药卫生—内科学]