精子获能与激素调节作用  

Sperm Capacitation and Regulation of Hormones

作　　者：朱子玉[1] 寇朝辉[1] 陈大元[1] 

机构地区：[1]中国科学院动物研究所生殖生物学国家重点实验室

出　　处：《生殖与避孕》2003年第4期251-255,共5页Reproduction and Contraception

基　　金：中科院知识创新工程重大项目(KSCX1- 0 5 - 0 1)部分资助

摘　　要：精子获能的发现和体外获能的成功是体外受精的基础。有关精子体内和体外获能的实质及获能机制 ,以及存在于雌性生殖道或精浆中的激素包括雌激素、孕酮、催乳素和前列腺素及肽类生长因子如表皮生长因子 ( EGF)、受精促进肽 ( FPP)、白细胞介素 ( IL)等对精子获能的作用已有较多的研究报道 。The found of sperm capacitation and the success of capacitation in vitro are basic events to establish the techniques of in vitro fertilization(IVF). There were a series of reports about the substances of sperm capacitation in vivo and in vitro , the capacitation mechanism, and the effect of hormones existing in female reproductive tract or seminal plasma on sperm capacitation. In the mini review, author summarizes resent advances, in which the several hormones are reviewed, including estrogen, progesterone, prolactin, prostaglandins, and peptide growth factors, such as epidermal growth factor(EGF), fertilization promoting peptide(FPP), and interleukin. The studies on factors to associate with sperm capacitation will promote further application of IVF in human assistant reproduction and animal reproduction.

关 键 词：精子 获能 体外受精 激素 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]