国产环孢素A微乳胶囊血药浓度监测指标C_2与C_0的比较  

Comparison between C_2 and C_0 as a monitoring tool for domestic cyclosporin A microemulsion capsule

作　　者：钱方[1] 王海[1] 朱有华[2] 缪海均[1] 邓渝林[1] 刘皋林[1] 王亚伟[2] 郑军华[2] 

机构地区：[1]第二军医大学附属长征医院药学部,上海200003 [2]第二军医大学附属长征医院肾移植中心,上海200003

出　　处：《中华器官移植杂志》2003年第5期281-283,共3页Chinese Journal of Organ Transplantation

摘　　要：目的　探讨血中环孢素A(CsA)浓度的监测。方法　采用荧光偏振免疫测定法 (FPIA)测定 17例肾移植患者服用国产CsA微乳胶囊后不同时间的血药浓度 ,3P87药代动力学程序处理血药浓度 时间数据。结果　服药后 2h的浓度 (C2 )与 0～ 12h曲线下面积和 0～ 4h曲线下面积之间的相关性优于服药即刻浓度 (C0 ,P <0 .0 5 )。结论　对于服用CsA微乳胶囊者 ,根据C2 来调整CsA的用量 ,较C0 更有效、更安全。Objective To testify the possibility that two-hour concentration (C_2) substituting for the target concentration (C_0) is used to be a monitoring tool for CsA. Method The whole blood concentrations of CsA having taken orally in 17 renal transplant patients were measured by FPIA. The data of concentration-time was processed by 3P87 pharmacokinetic program. Results The correlation between C_2 values and AUC_ 0-4 , or AUC_ 0-12 was both more excellent than C_0( P < 0.05 ). Conclusion For those taking domestic cyclosporin A microemulsion capsule, C_2 as a surrogate monitoring tool to adjust the dosage of CsA is more effective and safe than C_0.

关 键 词：环孢素A 微乳胶囊 血药浓度 荧光偏振免疫测定法 药物代谢动力学 

分 类 号：R96[医药卫生—药理学]