哮喘病儿血清sC5b-9水平变化及意义  

THE CHANGES OF SERUM SOLUB LE C5b-9 CONCENTRATION AND CLINICAL SIGNIFICANCE IN CHILDREN WITH ASTHMA

作　　者：刘晓萍[1] 栾桂珍[1] 宋纪英[1] 冯金环[1] 

机构地区：[1]青岛海慈医疗集团海慈医院儿科,山东青岛266033

出　　处：《青岛大学医学院学报》2003年第4期444-445,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　探讨血清补体激活片段 (sC5b 9)与哮喘发病的关系。②方法　采用酶联免疫吸附法(ELISA) ,检测了 30例哮喘病儿哮喘发作时和发作缓解后 2 4h内血清sC5b 9浓度的变化 ,并与 30例健康儿童比较。③结果　哮喘病儿哮喘发作时血清sC5b 9浓度明显高于哮喘发作缓解后 ,且发作时和发作缓解后血清sC5b 9浓度明显高于对照组 (F =380 .5 3,q =37.4 9、9.4 1、2 8.0 8,P均 <0 .0 0 1)。 ④结论　sC5b 9可能参与了哮喘的发作 。Objective\ To explore the relationship betwee n the changes of serum complement activation components(sC5b 9)and episode of a sthma.\ Methods\ By using enzyme linked immune absorption assay(ELISA),th e serum sC5b 9 concentration was measured in 30 children with asthma during its episode and 24 hours after remission. The results were compared with 30 healthy controls.\ Results\ The serum sC5b 9 level during the attack was higher than that after the attack in the patients. The sC5b 9 levels both during the atta ck and remission were higher than that of the controls ( F=380.53; q=37.49,9.4 1,28.08; P <0.001).\ Conclusion\ Serum sC5b 9 may involve in the attack of asthma and is closely related to a patients condition.

关 键 词：哮喘 儿童 补体激活片段 酶联免疫吸附法 检测 诊断 

分 类 号：R725.6[医药卫生—儿科]