妊娠高血压综合征病人瘦素、胰岛素及C肽的检测及意义  

CHANGE OF PLASMA LEPTIN, INSULIN AND C-PEPTIDE IN PATIENTS WITH PREGNANCY-INDUCED HYPERTENSION

作　　者：李世红[1] 

机构地区：[1]临沂医学专科学校妇产科教研室,山东临沂276002

出　　处：《齐鲁医学杂志》2003年第4期394-395,共2页Medical Journal of Qilu

摘　　要：①目的　探讨妊娠高血压综合征 (妊高征 )与瘦素、胰岛素、C肽的关系。②方法　采用放射免疫分析法 ,测定 4 1例妊高征孕妇 (妊高征组 )和 4 1例正常孕妇 (对照组 )血浆瘦素、胰岛素、C肽的含量。③结果　妊高征组瘦素、胰岛素、C肽水平与对照组比较有显著差异 (t =7.14～ 18.77,P <0 .0 1) ,中、重度妊高征组血浆瘦素、胰岛素、C肽与轻度妊高征组比较 ,差异有显著性 (F =3.86～ 14 .5 2 ,q =3.5 2～ 10 .2 3,P <0 .0 5、0 .0 1)。Objective To investigate the relationships among pregnancy-induced hypertension (PIH) and plasma leptin, insulin and C-peptide levels. Methods Blood samples from 41 PIH patients and 41 normal pregnant women were collected, and the plasma leptin, insulin and C-peptide were detected by radioimmunoassay. The results were statistically analyzed. Results The PIH group differed significantly from the control group in the levels of leptin, insulin and C-peptide (t=7.14-18.77, P< 0.01). The patients with severe or moderate PIH differed significantly from those with mild PIH in the levels of leptin, insulin and C-peptide (F=3.86-14.52, q=3.52-10.23, P<0.05, 0.01). Conclusion High plasma leptin and insulinemia may play an important role in the development of PIH.

关 键 词：妊娠高血压综合征 瘦素 胰岛素 C肽 检测 放射免疫分析 

分 类 号：R714.246[医药卫生—妇产科学]