麝黄膏脐敷对难治性肝硬化腹水患者血流动力学与NO变化的影响  

EFFECTS OF SHEHUANGGAO APPLIED TO UMBILLICAL REGION ON THE HEMODYNAMICS AND CHANGES OF NO LEVEL IN PATIENTS WITH REFRACTORY ASCITES DUE TO CIRRHOSIS

作　　者：童光东[1] 周大桥[1] 贺劲松[1] 

机构地区：[1]广州中医药大学附属深圳医院,深圳518033

出　　处：《中国中医药科技》2003年第5期259-260,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：20 0 2年国家中医药管理局基金资助项目NO .0 2 -0 3LP39

摘　　要：目的 :观察麝黄膏脐敷对难治性肝硬化腹水患者血流动力学与NO变化的影响 ,探讨其疗效机理。方法 :5 9例难治性肝硬化腹水患者作为研究对象 ,其中 32例用麝黄膏脐敷为治疗组 ,同时予基础治疗 ;2 7例对照组只给予基础治疗。用比色法间接测定治疗前后血清NO含量 ,彩色多普勒测量门静脉血流并分析两者的相关性。结果 :治疗组患者NO水平疗后较疗前明显下降 (P <0 0 5 ) ,门脉血流量疗后亦较疗前明显下降 (P <0 0 5 ) ;对照组两者变化差异不显著。治疗组NO的变化与门脉血流量有一定相关性。结论Objective:To obsevve the effects of shehuanggao applied to umbillical region on the hemodynamics and changes of NO level in patients with refractory ascites due to cirrhosis and explore its mechanism.Metrod:59Cases with refractory ascites due to cirrhosis were observed,32 cases of treatment group were applied Shehuanggao to umbillical region and base treatment,27 cases of control were only given base treatment.plasma NO was determined by the colorimetry,the serum portal veinblood flow was determined by color Doppler,meanwhile analysing the relationship between blood flow and NO level. Results:The plasma NO level was significantly lower than before treated ( P <0 05),the blood flow of portal vein was obviously decreased ( P <0 05); the changes of above two indexes were not obvious in control group.There was multiple correlation coeffcient in treatment group between NO Level and blood flow of portal vein.Conclusion: Shehuanggao applied to umbillical region can significantly improve the hemody-namics and NO level in patients with refractory ascites due to cirrhosis.

关 键 词：麝黄膏 脐敷 难治性肝硬化 腹水 血流动力学 一氧化氮 中医药治疗 

分 类 号：R259.7[医药卫生—中西医结合]