丙型肝炎病毒包膜蛋白E2与 CD81关系的研究进展  

Research Progress of the Relationship between HCV Envelope Protein E2 and CD81

作　　者：代志琰[1] 

机构地区：[1]中山大学附属第三医院传染科,广州510630

出　　处：《中山大学研究生学刊（自然科学与医学版）》2003年第2期27-33,共7页Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)

摘　　要：丙型肝炎病毒(HCV)是慢性肝炎的主要病因之一,其基因组为单股正链 RNA,包膜蛋白 E2在 HCV 入侵宿主细胞中起重要作用,CD81可能是HCV 的受体或共同受体,进一步研究 CD81和 HCV E2的相互作用,有助于HCV 的治疗和预防。Hepatitis C virus(HCV)is the main cause of patients infected with chronic hepatitis. Binding of the HCV envelope protein E2 to CD81 provides a costimulatory signal for human cells. CD81 molecule may be a putative receptor for HCV and represent one of the pathways by which HCV can infect hepatocytes.This phenomenon may play a role in liver damage and autoimmune manifesta- tions associated with HCV infection.Further studies on interaction between CD81 and HCV E2 will be helpful in prevention and treatment of HCV.

关 键 词：丙型肝炎病毒 包膜蛋白E2 CD81 研究进展 受体 相互作用 致病机制 

分 类 号：R373.21[医药卫生—病原生物学]