PON1基因表达与湖南汉族慢性肾衰发生有关  

Paraoxonase 1 Gene Expression Is Associated with Chronic Renal Failure in the Hans of Hunan Province

作　　者：文军[1] 伍洪波[2] 宋丽华[1] 徐明[1] 郭兆贵[1] 

机构地区：[1]中南大学分子药物与治疗研究所,湖南长沙410078 [2]湖南省卫生厅医学考试培训中心

出　　处：《中国医师杂志》2003年第10期1302-1303,1304,共3页Journal of Chinese Physician

基　　金：湖南省卫生厅医药卫生科研计划项目 (0 0 0 0 4 )

摘　　要：目的　探讨血清PON 1酶活性、PON 1Q192R基因多态性与湖南汉族慢性肾衰病人的关系。方法　对 79例湖南汉族慢性肾衰病人及 90例对照组的血清PON 1酶蛋白水平、PON 1Q192R基因多态性进行检测。结果　慢性肾衰病人组血清PON 1酶活性 ( 3 72 6± 15 0 6)U显著低于对照组 ( 5 3 7 8± 172 2 )U ,两者比较 ,差异有显著性 (P <0 0 1) ;慢性肾衰病人组PON 1AB +BB基因型频率明显高于对照组 ,基因型AB +BB/AA的优势比为 6 3 9( 95 %可信限为 2 5 0～ 16 3 5 ,P <0 0 1)。结论　PON 1基因表达与湖南汉族人慢性肾衰疾病发生有关 ,ABObjective To investigate the relationship among paraoxonase-1 (PON 1) activity in serum,PON 1 Q192R polymorphism and chronic renal failure disease ( CRF ) in the hans of Hunan.Methods PON 1 activity in serum and PON 1 Q192R polymorphism of 79 patients with CRF and 90 healthy subjects as control were measured.Results PON 1 activity in serum of patients with CRF (372 6±150 6)U was significantly lower than that in control group (537 8±172 2)U(P<0 01).The frequencies of AB±BB genotype of PON 1 gene in CRF group were significantly higher than those in control group, and the odds ratios ( OR ) of AB + BB / AA genotype were 6 39 ( 2 50～16 35).Conclusions The overall data suggest that paraoxonase 1 gene expression is associated with CRF in Hunan Hans and the Q192R polymorphism of PON 1 gene may be one of the risk factors and susceptible genetic markers for CRF in Hunan Hans.

关 键 词：二乙基对硝基苯磷酸酯酶 I型基因 慢性肾衰 多态性 

分 类 号：R692.5[医药卫生—泌尿科学]