低分子量肝素治疗重症急性胰腺炎的临床研究  

Clinical Study of Treatment of Low Molecular Weight Heparin

作　　者：李介秋[1] 张开诚[1] 吕新生[2] 李汉军[1] 徐文标[1] 樊光辉[1] 

机构地区：[1]解放军第163医院普外科,湖南长沙410003 [2]中南大学湘雅一医院普外科,湖南长沙410008

出　　处：《中国医师杂志》2003年第10期1341-1342,共2页Journal of Chinese Physician

摘　　要：目的　探讨低分子量肝素 (LMWH)对重症急性胰腺炎 (SAP)患者的疗效。方法　随机分为LMWH治疗组 (LT组 ) 77例和对照治疗组 (CT组 ) 65例 ,对比两组疗效。结果　LT组 77例中治愈 70例 ( 90 9% ) ;CT组 65例中治愈 48例 ( 73 8% ) ;LT组的并发症率 2 8 6% ( 2 2例 45次 )明显偏低于CT组并发症 60 % ( 3 9例 79次 ) (P <0 0 1) ;LT组胰腺坏死灶清除加腹腔持续灌洗引流术的手术率 2 6%较CT组 2 6 2 %明显降低 (P <0 0 1) ;LT组平均住院日 ( 3 0± 8)d较CT组 ( 4 3± 11)d明显减少 (P <0 0 1)。结论　LMWH能在SAP早期改善胰腺微循环 ,减轻缺血再灌注损伤 ,使SAP疗效明显提高。Objective To explore the treatment effects of low molecular weight heparine (LMWH) on severe acute pancreatitis (SAP). Methods Random analysis were made on the clinical features and therapeutic effect on the control treatment group (CT) in 65 cases and LMWH treatment group (LT) in 77 cases.Results 70(90 9%) cases were cured in LT group,and 48(73 8%) cases were cured in CT group. The incidence of complications in the LT group (28 6%, 22patients 45 times) was significantly lower than that in the CT group (60%,39patients 79 times)(P<0 01). The operative rate of nectrotic pancreatic debridement in LT group (2 6%)was obviously lower than that in CT group (26 2%)(P<0 01). The average hospitalized time in LT group (30±8)d was significantly shorter than that in CT group(43±11)d (P<0 01). Conclusions LMWH can improve the microcirculation of pancrease at the early stage of SAP and promote the therapeatic effect of SAP.

关 键 词：肝素 低分子量肝素/治疗应用 胰腺炎/药物疗法 急性病 

分 类 号：R657.5[医药卫生—外科学]