肌钙蛋白检测对风湿病心肌损伤的临床意义  

Clinical Significance of Troponin Testing in Rheumatic Diseases with Myocardial Injury

作　　者：黄立群[1] 黄少弼[1] 

机构地区：[1]汕头大学医学院第一附属医院,广东汕头515041

出　　处：《中国医师杂志》2003年第10期1360-1361,共2页Journal of Chinese Physician

摘　　要：目的　探讨血清肌钙蛋白I(TnI)、肌钙蛋白T(TnT)与风湿性疾病心肌损伤的关系。方法　以固相层析法定性检测2 41例风湿病患者 ,其中系统性红斑狼疮 (SLE)组 67例 ,干燥综合征 (SS)组 3 1例 ,系统性硬化症 (SSc)组 18例 ,多发性肌炎 (PM )组 11例 ,类风湿关节炎 (RA)组 72例 ,强直性脊柱炎 (AS)组 42例的TnI、TnT ,且与正常对照组进行比较 ,其阳性率还与CK -MB阳性率进行比较。结果　除AS组外 ,各组血清TnI、TnT阳性率均较CK -MB阳性率高 ,其中SLE、SSc、RA组有显著性差异。同组血清TnI、TnT阳性率对比没有差异 ,对照组三项检测全部正常。结论　血清TnI、TnT检测可作为判断风湿病心脏损伤的敏感指标 ,起到早期心肌损伤的预警作用 。Objective To explore the relationship between serum troponin I (TnI) and troponin T (TnT) and rheumatic diseases with myocardial injury.Methods Solid chromatographic method was used to test serum TnI and TnT in 241 patients with various types of rheumatic diseases consisting of 67 cases of SLE, 31 cases of SS, 18 cases of SSc, 11 cases of PM, 72 cases of RA and 42 cases of AS, which were compared with the normal group, amd the positive rates of which were also compared with CK-MB.Results Among all 241 patients,the positive rates of serum TnI and TnT of each type of rheumatic diseases except AS were higher than that of CK-MB,and the p value in SLE, SSc and RA was significant respectively(P<0 05).The positive rates of the serum TnI and TnT in the same group had no significant difference,and the testing results of the control group were normal.Conclusions Testing serum TnI and TnT may be a sensitive marker for the diagnosis of rheumatic diseases with myocardial injury.It may be used as a effective waring index for doctors to take measures early to protect the patient hearts.

关 键 词：肌钙蛋白 风湿病 心肌损伤 

分 类 号：R541.2[医药卫生—心血管疾病]