氟替中空泡腾栓的研制  

Preparation of FLX-TNZ Hollow Effervescent Suppository

作　　者：张雷 李欣[2] 李中华 梁毅 陈涌江 

机构地区：[1]解放军第465医院,吉林市132013 [2]第四军医大学吉林军医学院药学教研室

出　　处：《中国药房》2003年第8期468-470,共3页China Pharmacy

摘　　要：目的 :建立氟罗沙星 -替硝唑中空泡腾栓的制备及质量控制方法。方法 :用36型半合成脂肪酸酯作基质制备氟罗沙星 -替硝唑中空泡腾栓 ;采用双波长紫外分光光度法同时测定氟罗沙星和替硝唑的含量。结果 :氟罗沙星和替硝唑平均回收率分别为99 72 %、99 08% (n=5) ,精密度分别为0 95%、1 02 %。结论 :本方法设计合理 。OBJECTIVE:To establish the preparation technic and method of qualit y control of fleroxacin-tinidazole(FLX-TNZ)hollow effervescent suppository METH ODS:36-type semi-synthetic aliphatic ester was used as base material and doub le-wavelength UV-spectrophotometry was adopted for determination of the conten ts of fleroxacin and tinidazole RESULTS:The average recovery rates(n=5)of fler oxacin and tinidazole were 99 72% and 99 08%,while RSDs were 0 95% and 1 02% respectively CONCLUSION:This method has a sound design and feasible tec hnnology

关 键 词：氟罗沙星-替硝唑中空泡腾栓 质量控制 制备工艺 36型半合成脂肪酸酯 双波长紫外分光光度法 

分 类 号：R944.23[医药卫生—药剂学] TQ460.6[医药卫生—药学]