青蒿琥酯与萘酚喹不同联用方案治疗抗药性恶性疟的效果  

EFFICACY OF ARTESUNATE-NAPHTHOQUINE COMBINATION AGAINST FALCIPARUM MALARIA

作　　者：李兴亮[1] 杨恒林[1] 杨品芳[1] 李春富[1] 李丽[1] 

机构地区：[1]云南省寄生虫病防治所,云南思茅665000

出　　处：《中国寄生虫病防治杂志》2003年第4期208-209,共2页Chinese Journal of Parasitic Disease Control

基　　金：联合国开发计划署/世界银行/世界卫生组织/热带病研究培训特别规划处(WHO/TDR;ID-971144);中国云南省卫生厅(No.98007)资助课题

摘　　要：目的 研究青蒿琥酯、萘酚喹不同联用方案治疗抗药性恶性疟的效果。方法 分别用青蒿琥酯200mg、萘酚喹400mg2d分服(A组)和青蒿琥酯300mg、萘酚喹600mg3d分服(B组)治疗恶性疟现症患者。结果 A组、B组各治疗48例和57例,平均退热时间分别为(24.8±5.3)h和(27.4±6.7)h,平均原虫无性体转阴时间分别为(31.4±9.9)h和(33.6±10.9)h,观察28d的治愈率分别为93.7％和94.4％,两组疗效无明显差别(x^2=0.0177,P>0.001)。结论 青蒿琥酯与磷酸萘酚喹联用是治疗抗药性恶性疟的有效组方。从延缓恶性疟原虫抗性角度等综合考虑,采用青蒿琥酯300mg、萘酚喹600mg3d分服方案治疗恶性疟患者较为适宜。Objective To observe the efficacy of artesunate-naphthoquine combination against falciparum raalaria. Methods each of 48 cases of falciparum malaria in group A were treated with total dosage of 200 mg artesunate plus 400 mg naphthoquine for 2 days, and each of 57 cases in group B were given total dosage of artesunate 300 mg and naphthoquine 600 mg for 3 days. Results The average fever clearance times in group A and B were (24. 8 ±5. 3) h and (27. 4± 6. 7) h; the asexual parasite clearance times were (31.4 ± 9. 9) h and (33. 6±10. 9) h, the cure rates for 28-day follow-up were 93. 7% and 94. 4%(P>0. 05), respectively. Conclusion The atesunate-naphthoquine combination against falciparum malaria has the advantage of high efficacy and low side effects.

关 键 词：青蒿琥酯 萘酚喹 联合治疗 抗药性恶性疟 体外药物敏感性 

分 类 号：R531.3[医药卫生—内科学] R969[医药卫生—临床医学]