围产儿出生缺陷危险因素的Logistic配对研究  

Case-control study of conditional logistic regression on risk factors of perinatals' birth defects

作　　者：覃丹丹[1] 仇小强[1] 曾小云[1] 钟喜红 林墨菊 张宏丽[4] 黄栋[1] 

机构地区：[1]广西医科大学公共卫生学院流行病学教研室,南宁530021 [2]广西南宁市卫生局 [3]广西柳州市妇幼保健院 [4]广西南宁市妇幼保健院

出　　处：《中国公共卫生》2003年第9期1061-1062,共2页Chinese Journal of Public Health

基　　金：广西自然科学基金项目 (991 2 0 2 6)

摘　　要：目的　探讨广西围产儿出生缺陷发生的各种危险因素 ,并规划出生缺陷的干预措施。方法　用条件Logistic回归模型对广西 2 0 0 0年 2 76对围产儿 (配对病例对照 )的父母所暴露的环境危险因素进行分析。结果　有统计学意义的危险因素是 :母亲孕期接触农药 (OR =5 76 4 ) ,孕期营养不良 (OR =4 5 95 ) ,父亲接触化学制剂 (OR =2 5 0 5 ) ,孕期接触化学制剂 (OR =2 331) ,产次 >2 (OR =1 934) ,孕期体力劳动过重 (OR =1 4 80 ) ,孕期不良情绪(OR =1 4 6 0 )等与出生缺陷的发生有关。结论　在广西进行出生缺陷干预可从职业因素、营养因素及心理因素等方面入手。Objective To explore the risk fctors for the occurrence of the perinatals' birth defects in Guangxi province and plan some intervention measures.Methods Using conditional logistic regression to analyse environmental risk factors which 276 pairs perinatals'(pair matching case-control) parents were exposed to in Guangxi province in the year 2000.Results Statistically significant(α<0 05) risk factors were:maternal pesticide exposure during pregnancy ( OR =5 764),maternal malnutrition during pregnancy ( OR =4 595),paternal chemicals exposure( OR =2 505),maternal chemicals during pregnancy( OR =2 331),meternal parity more than twice( OR =1 934),maternal overloaded physical labor during pregnancy( OR =1 480),maternal unhealthy feelings during pregnancy( OR =1 460),which seemed relevant to the occurrence of the birth defects.Conclusion Birth defects can be intervened in the respects such as vocational factors,nutritional factors and psychological factors in Guangxi.

关 键 词：出生缺陷 危险因素 配对病例对照研究 

分 类 号：R195.1[医药卫生—卫生统计学]