严重少精、无精患者无精子因子(AZF)的检测及意义  

Screening of AZF microdeletion in the patients with azoospermia or severe oligozoospermia

作　　者：赵力新[1] 卢少明[1] 李媛[1] 王丽[1] 陈子江[1] 

机构地区：[1]山东大学山东省立医院生殖医学中心

出　　处：《山东大学学报（医学版）》2003年第4期445-446,454,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨无精子因子(azoospermiafactor,AZF)与不育男性精子生成的关系。方法:检测79例无精、严重少精不育男性及10例正常生育男性的AZF基因缺失状况,并根据是否合并有其他男性学检查异常,将受检患者进一步划分为原发性和非原发性男性不育两组,比较各组间AZF基因缺失的检出率。结果:79例受检的无精或严重少精患者有8例(10.1%)AZF基因缺失,10例精液正常生育男性均未见有基因缺失。61例无精子和18例严重少精患者,分别检出6例(9.8%)和2例(11.1%)AZF基因缺失,两组AZF缺失检出率无统计学差异(P>0.05)。34例原发性和45例非原发性男性不育患者,分别有6例(17.6%)和2例(4.4%)AZF缺失,两组缺失检出率有统计学差异(P<0.05)。结论:AZF与精子生成障碍密切相关,它是原发性无精或严重少精的重要病因之一。Objective:To evaluate the relationship between microdeletion of azoospermia factor(AZF)and male spermatogenic failure.Methods:AZF was tested in79patients with azoospermia or severe oligo-zoospermia and10healthy controls.On the base of whether or not with abnormal andrological findings,the patients were further divided into idiopathic infertility and non-idiopathic infertility groups.Results:No mi-crodeletion was found in10controls,but microdeletion was found in8(10.1%)of the79patients.There was no significant difference of deletion incidences between azoospermic and severe oligozoospermic groups which were9.8%(6/61)and11.1%(2/18)respectively,but there was significant difference between idio-pathic and non-idiopathic male infertile groups with17.6%(6/34)and2.2%(2/45)deletion incidence re-spectively.Con clusion:Microdeletion of AZF is related with azoospermia or severe oligozoospermia,and may be one of reasons of idiopathic azoo-or severe oligozoo-spermia.

关 键 词：无精子因子 无精 严重少精 不育 男性 

分 类 号：R698.2[医药卫生—泌尿科学]