一种新的长效制剂体外释放方法——等距浸出法  

A novel release method of sustained-release preparations in vitro :equal distance release method

作　　者：王世亮[1] 储成顶[1] 刘飞[1] 俞敏[1] 鲍玉婷[1] 

机构地区：[1]合肥工业大学控释药物研究所

出　　处：《中国新药杂志》2003年第8期627-630,共4页Chinese Journal of New Drugs

基　　金：中华人民共和国科学技术部基础研究快速反应支持项目 (国科基字 [2 0 0 1] 5 1号 )

摘　　要：目的 :建立一种适用于长效药物的体外释放新方法。方法 :依据杯法原理 ,以断续浸出的方式进行长效制剂的体外释放试验 (等距浸出法 )并予数学证明。结果 :等距浸出法与杯法的数学模型相吻合 ,对比实验也揭示两法的试验结果呈显著性相关。结论 :等距浸出法简单实用 ,是一种较好的长效制剂的体外释放新方法。Objective:To establish a novel release method of sustained-release medications in vitro . Methods: Based on the principle of cup-method,the release experiments on sustained-release preparations(The equal distance release method) were conducted in vitro with the model of spiccato release,and the validity of the method was attested mathematically. Results: The mathematical model of equal distance release method accorded with that of cup-method release.The comparative study revealed a significant correlation between the results of the two methods. Conclusion: The equal distance release method is a simple,practical method,and is a better release method of sustained-release preparations in vitro .

关 键 词：长效制剂 体外释放 等距浸出法 等时间距 等释放度距 

分 类 号：R944.9[医药卫生—药剂学]