血塞通注射液对大鼠多发性脑梗死作用的实验研究  

Study on Xuesaitong Injection on Multiple Cerebral Embolisms in Rats

作　　者：李克玲[1] 王谦[1] 黄启福[1] 蒋玉凤[1] 严京[1] 贾旭[1] 李伯光[1] 陈永红[1] 杨丽萍[1] 张宇忠[1] 王文荣[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《中国中医急症》2003年第5期455-456,共2页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的探讨血塞通注射液治疗多发性脑梗死的作用机制。方法按文献方法复制多发性脑梗死大鼠模型,随机分为模型组和血塞通注射液高、中、低剂量组,并与对照组比较。观察各组脑组织含水量、脑组织病理形态学变化及海马神经元变性坏死的情况。结果血塞通注射液能改善多发性脑梗死大鼠的脑水肿,促进脑软化灶的胶质细胞反应,加速软化灶的吸收和机化,对海马神经元继发性损伤有保护作用。结论血塞通注射液对大鼠多发性脑梗死有较明显的治疗作用。Objective:To observe of the effect of Xuesaitong Injection on the water content changes and the histo -pathological changes in model of multiple cerebral emboli sms in rats.Methods:The model of multiple cerebral embolisms in rats was established by the in-jection of autogeneic blood clot suspension into left internal carotid a rtery.The water contents in brain were measured at th e moments of day 1,day 3,day 7and day 14after multiple cerebral embolism by weigh ing the wet and dried brain tissue.The conditions of the histo -pathological changes and the hippocampus neuron degeneratio n and necrosis of the brain tissue were observed by microscope.Results:The results showed that the brain water contents were increased significanlty in model of the multip le cerebral em-bolisms.Xuesaitong Injection markedly decreased the water conten t and,at the same time,the conditions of the histo -pathological changes and the hippocam pus neuron de-generation and necrosis of the brain tissue were improved to some extent.Conclusion:These results suggested that Xuesaitong Injection be proved of effective protection to the lesion of the multiple cerebral embolisms in rats.

关 键 词：血塞通注射液 大鼠 多发性脑梗死 作用机制 病理形态学 海马神经元 脑水肿 

分 类 号：R277.733.3[医药卫生—中医学] R285.5