罗格列酮的降压作用及降压机理的研究  

The study of Rosiglitazone decrease the blood pressure and its mechanisms

作　　者：孔俭[1] 孙捷[1] 马丽[2] 汲宏磊[1] 

机构地区：[1]吉林大学第一医院干部病房,吉林长春130021 [2]吉林大学第一医院核医学科,吉林长春130021

出　　处：《中国老年学杂志》2003年第9期565-566,共2页Chinese Journal of Gerontology

摘　　要：目的　评价胰岛素增敏剂罗格列酮对自发性高血压大鼠的降压作用 ,并初步探索其降压作用机理 ,特别是对内皮素 - 1、瘦素的影响。方法　自发性高血压大鼠 36只 ,随机分为 3组 ,罗格列酮和硝苯地平分别作为观察药和阳性对照药添加到大鼠饮水中 ,另有一组为空白对照 ,仅给予清水。血压测定采用间接方法 ,其他指标检测采用放免的方法。结果　 2种药物均呈现显著的降压作用 ,内皮素、瘦素在罗格列酮组发生显著差异。结论　罗格列酮可以显著降低自发性高血压大鼠的血压 ,其作用机理之一是影响一些细胞因子水平。Objective To illuminate the effects of insulin sensilizer on spontaneously hypertensive rats and its mechanisms.Methods 36 spontaneously hypertensive rats were dividied into3-groups. Rosiglitaazone and Nefidipine were given in drinkingwater. The indexes of blood pressure, endothelin and leptin were examined.Results Both agents could reduce the blood pressure, but only Rosiglitazone influences the endothelin and leptin.Conclusions Insulin sensilizer-Rosiglitaze could significantly reduce the blood pressure of spontaneously hypertensive rats. And it does so by influencing endothelin and leptin.

关 键 词：罗格列酮 作用机理 胰岛素增敏剂 原发性高血压 大鼠 细胞因子 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病] R965[医药卫生—内科学]