养寿丹对Alzheimer病肾阳虚模型大鼠中枢胆碱能神经递质和细胞因子的影响  

Effect of Yang Shou Dan on IL-1 β、 AchE Response Elements of APP Protein in Rat Model with Alzheimer's Disease Combining Yang Deficiency of Kidney

作　　者：刘明平[1] 黄兆胜[1] 孙维广 

机构地区：[1]广州中医药大学中药学院,广东广州510405 [2]广州星群药业股份有限公司,广东广州510420

出　　处：《中国实验方剂学杂志》2003年第5期19-21,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的 :观察养寿丹对淀粉样前体蛋白基因启动因子IL 1β、AChE的影响。方法 :用D 半乳糖致亚急性衰老、醋酸氢化可的松致肾阳虚合并Meynert核损毁造成阿尔茨海默病肾阳虚大鼠模型 ,检测大鼠脑组织内IL 1β、AchE的含量。结果 :模型组大鼠脑组织IL 1β含量较正常组大鼠显著增高 (P <0 0 1) ;与模型组比较养寿丹高、低剂量组和脑复康组大鼠脑IL 1β含量显著降低 (P <0 0 1,P <0 0 5 ) ,但与正常组比较无显著性差异 (P <0 0 5 )。模型组大鼠大脑皮层、海马AchE含量较正常组增高 ,有显著性差异 (P <0 0 1) ,养寿丹可明显降低模型大鼠皮层及海马中AchE含量 ,其中高剂量更显著 (P <0 0 1)。结论 :提示养寿丹可调控阿尔茨海默病肾阳虚模型大鼠淀粉样前体蛋白基因启动因子IL 1β、AchE在体内的含量 ,使异常增高降低。Objective To observe the effect of Yang Shou Dan(YSD) on IL-1 β、AchE response elements of APP protein. Methods:Alzheimer's disease (AD) combining Yang deficiency of Kidney rats model was established by intraperitoneral injection of D-galgctose and intramuscularly injection of prednisolone acetate combined with ibotenic acid injection into bilateral nucleus basalis of Meynert. IL-1 β and AchE were inspected in the brain of rats. Results IL-1 β in model rat was significantly increased compared with the control group (P<0.01). YSD and Piracetam tablet reduced IL-1 β notably (P<0.01,P<0.05) Compared with the model. However, there was no difference with control group (P>0.05). AchE in hippocampus and cerebral cortex was elevated in model rat brain (P<0.01). YSD lowered AchE and the function of high dose was prominence (P<0.01). Conclusion:It is indicated that YSD can regulate IL-1 β, AchE response elements of APP protein in brain of mdel rat towards the normal levels.

关 键 词：养寿丹 阿尔茨海默病 肾阳虚 白细胞介素Ⅰ 乙酰胆碱酯酶 

分 类 号：R285.5[医药卫生—中药学]