辅舒酮吸入治疗前后哮喘儿童PEF的变化  

Changes of PEF in Children with Asthma Treated with Fluticasone Propionate

作　　者：顾秋枫[1] 林玉娟[1] 葛秋生[1] 

机构地区：[1]广东省深圳市北京大学深圳医院儿科,518036

出　　处：《齐齐哈尔医学院学报》2003年第8期844-845,共2页Journal of Qiqihar Medical University

摘　　要：目的 探讨辅舒酮吸入治疗前后儿童哮喘最大呼气峰流速(PEF)值的改变。方法 将52例应用皮质激素辅舒酮(FP)吸入治疗的哮喘儿童,年龄4～14岁,按病情分轻、中、重度三级,分别在用药前、用药后1个月、3个月、6个月及12个月测定PEF值,并观察用药过程中肺功能改善情况及出现的不良反应。结果 三级患儿用药后肺功能均较用药前明显改善,P<0.01,其中用药后3个月肺功能基本达预计值的80％以上,用药中不良反应少,主要表现为声嘶、鼻塞共3例(5.8％),加强漱口后症状消失,无1例发生口腔霉菌感染及全身不适。结论 辅舒酮吸入治疗儿童哮喘,在常规剂量下疗效好、安全,使用方便,无明显不良反应。Objective To observe the changes of peak expiratory flow (PEF) in children with asthma before and after inhaling Fluticasone Propionate (FP). Methods 52 cases of asthma, aged from 4 to 14, were classified as light, middle, and severe grades according to the children's conditions, and then treated with FP. The values of PEF before and after 1,3,6,12 months' treatment were detected. The pulmonary function and side effects of the drug were observed. Results The values of PEF in all patients were greatly improved after using FP (P<0. 01) , particularly after 3 months' treatment. There were a few side effects including hoarseness and nasal obstruction in 3 cases, which disappeared after rinsed out. No case occurred oral meiotic infection and general malaise. Conclusions It is safe and reliable for the children with asthma to use FP aerosol in route doses.

关 键 词：辅舒酮 吸入治疗 哮喘 儿童 最大呼气峰流速 治疗前后 

分 类 号：R725.622.5[医药卫生—儿科]