β-内啡肽与PRL在内异症不孕妇女中的变化研究  

The Role of Beta-endorphin and PRL in Endometriosis-associated Infertility

作　　者：徐琳[1] 杨映芳[1] 王秀丽[1] 李庆云[2] 单朝屏[1] 

机构地区：[1]昆明医学院第一附属医院妇产科,昆明650032 [2]昆明医学院第一附属医院核医学科,昆明650032

出　　处：《昆明医学院学报》2003年第3期50-53,共4页Journal of Kunming Medical College

摘　　要：目的 :通过对子宫内膜异位症不孕状态下 β -内啡肽 (β -EP)和泌乳素 (PRL)水平的测定及其相关性分析 ,初步探讨 β -EP对PRL分泌的影响及在内异症不孕发生中的可能作用 .方法 :以内异症不孕患者为研究对象 ,内异症妊娠、输卵管阻塞性不孕和正常妇女为对照组 ,检测卵泡晚期或黄体期血浆 β -EP和血清PRL水平 ,并分析 β -EP与PRL水平变化的相关性 .结果 :(1)内异症不孕和内异症妊娠妇女无论卵泡晚期或黄体期血浆 β -EP、血清PRL水平都升高 (P <0 0 1) ,内异症不孕患者变化较内异症妊娠妇女明显(P <0 0 5 ) . (2 )内异症不孕和内异症妊娠妇女无论卵泡晚期或黄体期 β -EP与PRL水平的变化都具有相关性 (P <0 0 5 ) .结论 :内异症患者体内 β -EP和PRL水平明显增高 ;PRL水平增高与 β -EP有关 ;βTo investigate the possible roles of Beta-endorphin(β-EP) and PRL in the aetiology of endometriosis-associated-infertility (EAI). Methods: Blood was drawn from EAI, EMT, tubal factor infertility and normal women during the follicular phase or luteal phase to determine the concentrations of β-EP and prolaction(PRL) and the correlation between β-EP and PRL was analyzed. The concentrations of β-EP and PRL in the blood of EAI and EMT patients are higher(P<0 05) than the contrasts regardless of follicular phase and luteal phase. These changes are more obvious (P<0 05) in EAI women. There is a significant correlation between the concentration of β-EP and PRL. The secretions of β-EP and PRL are raised in EAI and EMT. β-EP correlates with the secretion of PRL. β-EP and PRL are the possible reasons which result in the EAI.

关 键 词：子宫内膜异位症 不孕 β—内啡肽 泌乳素 测定 治疗 

分 类 号：R711.71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]