造血调控的主要细胞因子及通路  

Cytokine networks and signal pathways in regulating hemopoietic stem cell proliferation and differentiation

作　　者：杨玲[1] 刘善荣[1] 刘厚奇[1] 

机构地区：[1]第二军医大学基础医学部组织胚胎学教研室,上海,200433

出　　处：《第二军医大学学报》2003年第9期966-968,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金 ( 3 0 170 468) .

摘　　要：血液中的血细胞均来自于造血干细胞 ,发育中的脊椎动物的许多结构中都存在造血干细胞。造血过程是一个持续的动态的过程 ,在此过程中 ,造血干细胞及造血祖细胞的活动均要受到各种细胞因子的调节。一些特殊的细胞因子可以作用于多个靶细胞 ,具有多种活性。它们通过与受体的相互作用进行信号转导 ,通过信号转导来调节造血干细胞及祖细胞的生存、增殖、分化及迁移。All types of blood cells are derived from a common precursor:the hematopoietic stem cell.Hematopoietic stem cells can be found in different locations of the developing vertebrate organism. Hematopoiesis is a dynamic process sustained by cytokine induced production and activities of hematopoietic stem and progenitor cells.A number of different cytokines,cells,and cytokine cell interactions are involved in regulating the hematopoiesis. Some cytokines have more than one functions partially due to their actions on different target cells.These actions are mediated through specific receptors transmiting intracellular signals.These signals give the stem and progenitor cells critical information to survive,proliferate, differentiate or to migrate. This paper is to review recent developments in some of the major signal transduction pathways influencing hematopoietic growth and differentiation with a particular emphasis on myeloid cells.

关 键 词：造血调控 细胞因子 造血干细胞 综述文献 

分 类 号：R331.2[医药卫生—人体生理学]