舍曲林联合氯硝西泮治疗氯丙咪嗪无效的强迫症  

Sertraline Combined with Clonazepam in the Treatment of Clomipramine-resistant Obsessive-compulsive Disorders

作　　者：贾占玲[1] 

机构地区：[1]山东省济宁市精神病防治院精神科,272051

出　　处：《医药导报》2003年第10期682-683,共2页Herald of Medicine

摘　　要：目的:探讨舍曲林联合氯硝西泮对氯丙咪嗪治疗无效的强迫症的疗效。方法:对52例氯丙咪嗪治疗无效的强迫症住院患者随机分为治疗组和对照组各26例。治疗组给予舍曲林50mg·d-1,3 d后增至100 mg·d-1,氯硝西泮4mg·d-1,3 d后增至8 mg·d-1,均口服;对照组仅给予舍曲林,用法同治疗组。疗程均为8周。采用Yale-Brow强迫量表(Y-Bocs)和副作用量表(TESS)评定疗效和不良反应。结果:治疗组显效率64.5％,对照组显效率38.5％;治疗第4,8周末Y-Bocs评分治疗组优于对照组(P<0.05);不良反应两组差异无显著性(P>0.05)。结论:舍曲林并氯硝西泮治疗氯丙咪嗪无效的强迫症安全,有效。Objective: To study the therapeutic effects of sertraline combined with clonazepam in the treatment of clomipramine-resistant obsessive-compulsive disorders(OCD). Methods:52 patients with OCD resistant to clomipramine were randomly divided into two equal groups. 26 cases in the treatment group were given each 50 mg·d-1 of sertraline PO and 4 mg·d-1 of clonazepam PO in the beginning. 3 days later, the doses of sertraline and chonzepam were increased to 100 mg·d-1 and 8 mg·d-1 PO, respectively. 26 cases in the control group were given sertraline only in a dosage same as that of the treatment group. The course of treatment in both groups lasted 8 weeks. The therapeutic effectiveness was assessed with the Yale-Borwn obsessive-compulsive disorder rating scale(Y-Bocs) and adverse reactions were appraised with the treatment emergent symptom scale(TESS) . Results: The rate of notable effectiveness in the treatment group was 64.5% , while that of the control group, 38.5% . The score of Y-Bocs in the treatment group was significantly lower than that in the control group at the end of the 4th and 8th week( P < 0. 05). The difference was insignificant between the adverse reactions of the two groups( P > 0.05) . Conclusion: Sertraline combined with clonazepam was shown to be safe and effective in the treatment of clomipramine resistant OCD.

关 键 词：舍曲林 氯硝西泮 强迫症 

分 类 号：R971.4[医药卫生—药品] R749.3[医药卫生—药学]