不同剂量紫草醇提取物对鼠尾角化异常的恢复作用  

The Normalizing Effect of Alcohol Extracts from Zicao with Different Doses on Psoriatic Parakeratosis Mice Tails

作　　者：刘梅青[1] 

机构地区：[1]山西省太原市中心医院皮肤科,030009

出　　处：《岭南皮肤性病科杂志》2003年第3期145-147,共3页Southern China Journal of Dermato-Venereology

摘　　要：目的 :研究不同剂量紫草醇提取物对正常鼠尾样角化异常病理模型的作用。方法 :以不同剂量醇提取物给模型鼠灌胃 ,光镜下计数每 1 0 0个鼠尾鳞片的颗粒层形成数。结果 :不同剂量紫草醇提取物均有明显作用 (P <0 0 1 ) ,剂量与作用呈直线正相关 (r=1 30 3)。结论 :不同剂量紫草醇提取物对恢复鼠尾角化异常均有明显作用 ,量效呈正相关性。Objective:To explore the effect of alcohol extracts from Zicao on psoriatic parakeratosis. Methods:The model mice were orally administrated with different doses of alcohol extracts;the stratum granulosum laminas of 100 scales on mice tails were examined by LM.Results:The different doses were showed obvious effect (P<0.01),and have a linear correlation (r=1.303). Conclusion:Different doses of alcohol extracts from Zicao markedly normalized the parakemtosis of mice tails squamous epidermis, and have a positive dose-effect correlation.

关 键 词：紫草醇提取物 鼠尾角化异常 恢复作用 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]