山楂精降脂片对高脂大鼠及家兔血脂的影响  

Effect of Hawthorn Fruit on Blood-lipid Concentration in Rat and Rabbit With Hyperlipemia

作　　者：赵迅霞[1] 陈健茂[2] 李红兵[2] 石滨[2] 杨卫东[2] 曹军[3] 

机构地区：[1]宁夏医学院机能实验中心,银川750004 [2]宁夏医学院实验动物中心,银川750004 [3]宁夏医学院病理生理学教研室,银川750004

出　　处：《宁夏医学院学报》2003年第4期258-260,共3页Journal of Ningxia Medical College

摘　　要：目的:观察山楂精降脂片对高血脂大鼠及家兔血脂的影响。方法:随机将大鼠与家兔分别分为正常对照组、高脂组、大剂量山楂精降脂片组(3.0g/kg)、小剂量山楂精降脂片组(1.5g/kg),连续灌胃28d后,测定血清总胆固醇(TC),甘油三脂(TG)。结果:与高脂组相比,不同剂量山楂精降脂片对大鼠及家兔的血清总胆固醇、甘油三脂均有降低作用,大剂量组的作用更明显(P<0.01)。结论:山楂精降脂片是一种安全有效的降血脂药物。Objective: To observe the step-down action of hawthorn fruit tablet on blood -lipid concentration in rat and rabbit with hyperlipemia. Methods: Forty male rats were randomly divided into 4 groups; namely normal control group, taking basic forage; hyperlipemia control group, taking high lipid forage; low dosage hawthorn tablet group, feeded with hyperlipid forage and given hawthorn tablet in dosage of 1.5g/kg /bw by ig; high dosage hawthorn tablet group, feeded with high lipid forage and given hawthorn tablet in dosage of 3.0g/ kg/bw by ig. Four weeks later, all rats were killed and blood lipid concentrations were determined chemically. 2.Twenty rabbits were randomly divided into 4 sroups. Other procedures were the same as being adopted in rats. 3.LD50 of hawthorn tablet was determined in mice by routine method. All data were statistically analysed. Results : 1. The largest tolerance dosage of hawthorn in mice was over 18. 0g/kg b. w. showing no acute toxicity. 2. TC and TG in high dosage hawthorn tablet group rats were significantly decreased, compared with hyperlipemia control rats P< 0.01. 3. TC and TG in both low and high dosage group rabbits were significantly lower than that in hyperlipemia control rabbits. Conclusion: Hawthorn fruit tablet seems to be an effective and safe hypolipemia agent.

关 键 词：山楂精降脂片 高脂血症 大鼠 家兔 血脂 

分 类 号：R285[医药卫生—中药学]