山茱萸水提取物对肾阳虚动物模型肝脏和睾丸影响的实验研究  

Experimental Study on Effect of the Water Extract of Dogwood Fruits on the Liver and Testis in Rats Model of Kidney-yang Deficiency

作　　者：李春生[1] 张国玺[1] 石体仁[1] 董小霞[1] 孙丕[2] 李电东[2] 许鸿章[2] 陈可冀[1] 

机构地区：[1]中国中医研究院西苑医院,北京100091 [2]中国医学科学院协和医科大学医药生物技术研究所,北京100050

出　　处：《中国中药杂志》2003年第8期743-746,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目 ( 39170 878)

摘　　要：目的 :探讨山茱萸补肾阳作用。方法 :应用氢化考的松所致的肾阳虚动物模型 ,观察山茱萸水溶物对肾阳虚大鼠的影响。结果 :山茱萸水溶物具有使肾阳虚大鼠肝脏重量接近正常 ,肝细胞病理改变减轻 ,肝细胞RNA和糖原含量升高 ,丙二醛含量下降 ;它还能使肾阳虚大鼠睾丸脏器系数向正常方向逆转 ,使睾丸间质细胞内RNA含量增加。结论Objective:To explore the effect of Dogwood fruits on tonifying kidney yang. Method:The effect of the water extract of Dogwood fruits on rats model of kidney yang deficiency with the hydrocortisone was observed. Result:The water extract of Dogwood fruits could make normal the liver weight ,and mitigate hepatocyte pathologic changes, increase the heptocellular levels of RNA and hepatin , and decrease the malondialdehyde (MDA) in rats model of kidney yang deficiency. It could also make the viscera quotiety return to normal way and increase the levels of RNA in the interstitial cells of testicle in rats model of kidney yang deficiency.Conclusion: Water extract of Dogwood fruits can protect and improve the functions of the liver and testicle in rats model of kidney yang deficiency.

关 键 词：山茱萸 肾阳虚 肝脏 睾丸 动物实验 

分 类 号：R285.5[医药卫生—中药学]