益肾降压方对RPH大鼠降压及肾脏保护作用的研究  

Effects of Yishenjiangyafang on Blood Pressure and Protecting Renal Function in RPH Rats

作　　者：陈孟莉[1] 刘文军[2] 王彩云[1] 朱秀美[3] 殷建芬[1] 王东晓[1] 刘屏[1] 

机构地区：[1]解放军总医院临床药理研究室,北京100853 [2]中国中医研究院广安门医院,北京100050 [3]解放军海军401医院,山东青岛266001

出　　处：《中国中药杂志》2003年第8期746-751,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目 ( 3990 0 194 )

摘　　要：目的 :研究益肾降压方降低RPH大鼠血压、改善肾功能的作用及机制。方法 :采用大鼠 5/ 6肾切除术法建立RPH模型。动态测定血压、肌酐、尿素氮 ,及在给药 8周后测定血浆PAR ,AⅡ ,TXB2 ,6 酮 PGF1α的含量。同时观察给药 8周后RPH大鼠肾脏病理改变。结果 :各剂量益肾降压方均可降低RPH大鼠的BP ,Cr。但对RPH大鼠BUN未见影响 ;各剂量益肾降压方可显著降低血浆PAR ,AⅡ ,同时还可显著降低TXB2 含量 ,升高血浆 6 酮 PGF1α含量。各剂量益肾降压方组大鼠肾小球硬化 ,肾小管的萎缩均明显好于对照组和西药组。结论 :益肾降压方可降低RPH大鼠的血压 ,并对肾脏具有保护功能 ;益肾降压方的降压作用和对肾脏的保护功能是通过影响RPH大鼠肾素 血管紧张素Objective: To study the effects and mechanism of Yishenjiangyafang,a prescription of Chinese traditional herbs used for renal hypertension, on blood pressure and protecting renal function of RPH rats. Method: The 5/6 kidney of rat was resected to set up the RPH rat model. Blood pressure ,Cr(creatinine ), Ccr(creatinine clearance) and BUN(urea nitrogen) were measured dynamically. After eight weeks treatment, plasma content of PAR AⅡ TXB 2,6 keto PGF1 were measured. At same time,The change of renal pathology was observed. Result: Yishenjiangyafang could reduce blood pressure Cr , but had no effect on BUN of RPH rat. The indexes of PAR, AⅡ of each different dosage group of Yishenjiangyafang were decreased. At the same time, it reduced plasma content of TXB 2, and increased 6 keto PGF1α.Glomerulosclerosis and atrophy of renal tubule in Yishenjiangyafang group RPH rats were better than those of the contrast group and the Capten group. Conclusion: Yishenjiangyafang can reduce blood pressure of RPH rats and has protective effects on its kidney. Yishenjiangyafang can perform its effects of reducing blood pressure and protecting kidney by influencing the RAS of RPH rats.

关 键 词：益肾降压方 肾实质性高血压 中医药疗法 降压作用 肾脏保护作用 

分 类 号：R285.5[医药卫生—中药学]