曲美他嗪对老年急性心肌梗死患者的疗效  

Efficacy of Trimetazidine in Aged Patients with Acute Myocardial Infarction

作　　者：陈玉华[1] 周军[1] 朱燕[1] 周静[1] 顾锡华[1] 

机构地区：[1]上海第二医科大学宝钢医院心内科,上海201900

出　　处：《上海第二医科大学学报》2003年第5期460-462,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的 评价曲美他嗪与常规药物联合应用对老年急性心肌梗死患者的疗效及耐受性。方法 62例不适宜溶栓的老年急性心肌梗死患者于常规治疗1周后分为曲美他嗪治疗组(30例)和单纯常规治疗组(32例)。比较两组治疗前后心绞痛发作频率、发作时间、硝酸甘油消耗量、心功能指标的变化。结果 与治疗前相比,两组心绞痛发作频率、发作时间、硝酸甘油消耗量均显著减少,心功能指标改善(P<0.001),但这些有益作用在曲美他嗪治疗组较对照组更明显(P<0.001)。曲美他嗪治疗组中仅2例发生轻度胃肠道反应。结论 曲美地嗪与常规药物联合治疗老年急性心肌梗死安全有效。Objective To assess the efficacy and safety of trimetazidine (TMZ) in combination with conventional treatment in aged patients with acute myocardial infarction. Methods Sixty - two patients with acute myocardial infarction were randomly divided into two groups one week after conventional therapy. Thirty patients received additional TMZ treatment (20mg, three times daily) and 30 patients had conventional therapy only. The occurrence of angina, duration angina, nitrates consumption and left ventricular functional changes were compared after 12 weeks of medication. Results During TMZ treatment, duration of angina was significantly shortened, the number of angina attacts and mean nitroglycerin consumption per week were reduced (P < 0.001) , and left ventricular ejection fraction was improved ( P < 0. 001 ). TMZ group is more obvious than control group ( compared with control P <0. 001 ) . Only 2 patients treated with TMZ had slight gastric discomfort. Conclusion TMZ therapy is safe and effective in the treatment of aged patients with acute myocardial infarction.

关 键 词：老年 急性心肌梗死 药物治疗 曲美他嗪 

分 类 号：R542.22[医药卫生—心血管疾病] R972[医药卫生—内科学]