妊娠晚期妇女血清中肿瘤坏死因子-α水平与分娩  

Study on relationship between the level of TNF-α in serum from pregnant women of the third trimester and delivery

作　　者：毛立群[1] 李瑞民[2] 张明[3] 

机构地区：[1]武警医学院免疫学教研室,天津300162 [2]承德医学院微生物学教研室,河北承德067000 [3]天津医科大学免疫学教研室,天津300070

出　　处：《河北医学》2002年第4期296-298,共3页Hebei Medicine

摘　　要：目的 :旨在探讨肿瘤坏死因子 -α(TNF -α)与分娩的关系。方法 :采用MTT比色法分别对 30例正常晚期妊娠妇女和 2 0例妊高征妇女血清中的TNF -α水平进行检测。结果 :正常晚期妊娠妇女及妊高征妇女分娩前的血清TNF -α水平与分娩启动后相比均无显著性差异 ,P >0 .0 5 ;而妊高征妇女分娩前及分娩启动后血清TNF -α水平与正常晚期妊娠妇女相比均有显著性差异 ,P <0 .0 5。结论 :晚期妊娠妇女血清中的TNF -α水平与分娩的启动可能无关 。Objective: To investigated the relationship between the level of tumor necrosis-α(TNF-α) and delivery. Method: The level of TNF-α in the serum from 30 normal pregnant women of the third trimester and 20 patients with pregnancy-induced hypertension(PIH) was measured by MTT colorimetric analysis. Results: Compared with that before delivery, the level of TNF-α in the serum from the normal pregnant women and the patients with PIH during delivery was not significant statistically (P>0.05), but the level of TNF-α in the serum of the patients with PIH was higher than that from the normal pregnant women(including before and during delivery, P<0.05). Conclusions: TNF-α in the serum from pregnant women of the third trimester might not be associated with the mechanism of beginning of delivery, but the increased level of TNF-α might play a role in the development of PIH.

关 键 词：分娩 肿瘤坏死因子-Α 妊高征 

分 类 号：R714.7[医药卫生—妇产科学]