步行运动对慢性心力衰竭患者血浆肿瘤坏死因子及受体的影响  

Effect of walking movement on plasma TNF and receptor in chronic heart failure patients

作　　者：张福全[1] 刘建庄[2] 张三强[2] 袁麦顺 

机构地区：[1]安阳市人民医院高干病房,河南省安阳市455000 [2]河南新乡医学院第二附属医院心内科,河南省新乡市453002 [3]河南省内黄县第二人民医院心内科,河南省内黄县456300

出　　处：《中国临床康复》2003年第24期3348-3349,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察慢性心力衰竭(chronicheartfailure,CNF)患者血浆肿瘤坏死因子和受体水平的变化及步行运动对其影响,并探讨步行运动对慢性心力衰竭患者的治疗价值。方法:对81例心功能Ⅱ、Ⅲ级的CHF患者随机(随机数字表)分为运动治疗组(常规治疗+运动治疗)48例和对照组(仅常规治疗)33例。运动治疗方法;每天上、下午各作1次6min步行运动,总运动时间达到8周。运动组和对照组均在入院时和8周后的运动前后采取肘静脉血,测定血浆肿瘤坏死因子及其受体(STNFR)的水平。结果:入院时81例心功能Ⅱ、Ⅲ级的CHF患者运动后较运动前血浆TNF-α及STNFR水平均显著升高(t=2.730,P<0.01)。治疗8周后血浆TNF-α及STNFR水平明显下降(t=2.437,P<0.05),运动组运动前较对照组血浆TNF-α及STNFR水平下降更明显(t=2.428,P<0.05)。运动组治疗8周后的步行运动距离较对照组增加更明显(t=2.530,P<0.0)。结论:每天适当的运动可以有效降低CHF患者血浆炎性细胸因子的含量,有利于CHF患者的恢复。AIM:To observe the changes of the level th at plas ma tumor necrosis factor(TNF)and receptor in chronic heart failur e(CHF)patien ts and the effects of walking movement on them so as to in vestigate the treatab le value of walking movement for CHFpatients.METHODS :The 81patients with CH F(their cardiac function wereⅡorⅢstage)were randomly divided into 2groups: monement treatment group(treat by routine treatment and motorthera py n=48) and control group(routine treatmnt n=33).The methods of motortherapy:The patients made the walking movement for 6min in the morn ing and afternoon ever day for 8weeks.All of the patients were drew t he venous blood from the cubitu s befo re and when they were hospitalized at th e after the walking movement bey inin g of the treatment .The levels of TNF-a and STNFR in the blood plasma wer e assayed.RESULTS:At the beginning of the tratment,81p atients' walking mov ement than the levels of TNF-αand STNFRαbefore the walking movement (t=2 .730,P<0.01).The levels of TNF-αand STNFR in the blood plasma wer e obviously reduced after all the patients had been given the treatmen t for8we eks(t=2.437,P<0.05),and the patients levels of TNF-αand STNFR i n the group of movement treatm ent were obviously reduced before the movement co mpared with the group of control.All of the patients could do a longer distance of walking than they did not have the treatment ,but the group of movement tre atment could have a much longer distance of walking than the group of contrast( t=2.530,P<0.05).CONCLUSION:The patients with CHF make the ration al movement every-day,the content of inflamma cell in t he patients' plasma ca n be effectively reduced and the movement also is good at the patients' recovery .

关 键 词：步行运动 慢性心力衰竭 血浆 肿瘤坏死因子 受体 影响 

分 类 号：R541.6[医药卫生—心血管疾病]