吡啶斯的明对儿童生长激素分泌的影响及其临床意义  

EFFECT OF PYRIDOSTIGMINE ON SECRETION OF GROWTH HORMONE IN CHILDREN AND ITS CLINICAL SIGNIFICANCE

作　　者：李堂[1] 杜嗣廉[1] 杨立廷[2] 乔青[1] 林荣军[1] 连玉英[1] 

机构地区：[1]青岛医学院附属医院儿科 [2]青岛医学院附属医院内分泌实验室

出　　处：《青岛医学院学报》1992年第2期140-143,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：应用吡啶斯的明(PD)对15例正常儿童和16例生长激素(GH)缺乏症病儿进行GH激发试验,用放射免疫法测定GH.结果发现正常儿童服PD后GH明显升高,于60～90min达峰值.服药后60min GH显著高于左旋多巴试验(P<0.01),90min显著高于克罗宁试验(P<0.05).16例GH缺乏症病儿12例(75%)对PD无反应,4例(25%)出现GH升高,峰值超过5μg/L,与这些病例克罗宁和左旋多巴试验比较差异有极显著意义(P<0.01).提示PD试验是一项简单有效的GH激发试验,PD可能对某些GH缺乏症病儿有治疗价值.Growth hormone(GH)provocative test was done by oral administration of pyridostigmine(PD)in 15 healthy children and 16 patients with GH deficiency disease. The levels of GH were measured by radioimmunoassay. The results showed that the levels of GH in healthy children raised markedly after the administration of PD and arrived at a peak at 60 or 90 minutes. The GH levels were significantly higher than the results of the L-dopa test at 60 minutes (P<0.01),and higher than the results of the clonidine test at 90 minutes ( P<0.05 ).PD failed to increase the secretion of GH in 12 patients with GH deficiency (75%); however, increasing secretion (peak 5μg/L) was found in the other 4 patients(25%)and the peaks were significantly higher than those reached in the L-dopa test and clondine test ( P<0.01 ). The above suggests that PD test is a simple and effective GH provocative test and PD may have therapeutic value in some cases of GH deficieney disease.

关 键 词：吡啶斯的明 生长激素 儿童 

分 类 号：R723.190.5[医药卫生—儿科]