微波辐射促进腈类化合物水解  

Hydrolysis of Nitriles with Microwave Irradiation

作　　者：张青山[1] 陆宝萍[1] 郭炳南[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081

出　　处：《火炸药学报》2003年第3期73-75,共3页Chinese Journal of Explosives & Propellants

摘　　要：采用微波辐射反应技术研究了苯乙腈、对羟基苯甲腈和吲哚-5-甲腈在氢氧化钠水溶液中的水解条件及辐射功率和辐射时间对收率的影响。结果表明,最适宜的功率为530W,辐射时间分别为4,4.5,7min,制备出苯乙酸、对羟基苯甲酸和吲哚-5-甲酸的收率分别为87.9%,85.8%,89.6%。The hydrolysis of nitriles (benzyl cyanide(1),4hydroxybenzonitrile(2) and 5cyanoindole(3)) to give the corresponding acids (phenylacetic acid(4), 4hydroxybenzoic acid(5) and 1Hindole5carboxylic acid(6)) in the present of alkalis in water coupled with microwave irradiation was investgated. The optimum reaction conditions were determined through the test results. The optimum power of the microwave is 530 W and the optimum time of the reaction is 4 min for 1, 4.5 min for 2 and 7 min for 3, respectively. The yield is 87.9% for 4, 85.8% for 5 and 89.6% for 6 respectively.

关 键 词：微波辐射 腈类化合物 水解 苯乙腈 对羟基苯甲腈 吲哚-5-甲腈 苯乙酸 反应原理 

分 类 号：TQ241.21[化学工程—有机化工] O623.761[理学—有机化学]