^(117)Sn^m-胺基膦酸类配合物的生物分布研究  

BIODISTRIBUTION STUDY OF ^(117) Sn^m-RADIOPHARMACEUTICALS

作　　者：何佳恒[1] 罗顺忠[1] 蒲满飞[1] 王关全[1] 杨玉青[1] 蒋树斌[1] 王文进[1] 魏洪源[1] 邴文增[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900

出　　处：《核化学与放射化学》2003年第3期156-158,172,共4页Journal of Nuclear and Radiochemistry

基　　金：中国工程物理研究院军民两用基金资助项目(JM20008)

摘　　要：为了合成具有较高骨摄取和较低血液、肌肉、脾、肺摄取的放疗药物,以用于骨癌和骨转移癌治疗,合成了4种117Snm 胺基膦酸类配合物,并对其在生物体内的分布进行了比较。研究结果表明,117Snm TTHMP可望成为骨肿瘤治疗药物。The preparation and in vivo biodistribution in m ice of several 117 Sn m labelled compounds are studied. The results indicate that the favourable half-life and decay characteristics of 117 Sn m in various stannic compounds, especially stannic-TTHMP. It appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake and the binding of 117 Sn m-TTHMP to bone is higher than that of 117 Sn m-DTPA. This makes it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.

关 键 词：^117Sn^m-胺基膦酸类配合物 生物分布 骨肿瘤 冶疗药物 表征 配体 

分 类 号：R318.08[医药卫生—生物医学工程] O641.4[医药卫生—基础医学]