脂质体中不同种类羧酸钾对草酸钙晶体生长的调控作用  

Effects of Different Kinds of Potassium Carboxylates on the Growth of Calcium Oxalate Crystals in Lecithin-Water Liposomes

作　　者：欧阳健明[1] 段荔[1] 何建华[1] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,暨南大学化学系广州510632

出　　处：《化学学报》2003年第10期1597-1602,共6页Acta Chimica Sinica

基　　金：国家自然科学基金重点项目 (No .2 0 0 31 0 1 0 );广东省重点攻关项目 (No .C31 40 1 );广东省自然科学基金重点项目 (No .0 1 32 0 2 );广州市重点科技项目 (No .SZ 6 1 3);广东省"千百十工程"优秀人才培养基金 (No .Q0 2 0 6 0 )资助

摘　　要：首次研究了卵磷脂 -水脂质体中不同种类羧酸钾对草酸钙 (CaOxa)晶体生长的调控作用 .加入一元KAc只诱导一水草酸钙 (COM)生成 .二元K2 tart在其浓度大于 1.0mmol/L时可以诱导三水草酸钙 (COT)生成 .而加入三元的K3cit和四元的K2 edta后 ,在不同的浓度下 ,可以分别诱导COM ,二水草酸钙 (COD)和COT的生成 .在低浓度 (0 3 3～ 3 3mmol/L)范围 ,随着K3cit或K2 edta浓度的增加 ,COM减少 ,COD含量增加 ;至中间浓度 (3 3～ 17mmol/L)范围 ,COD含量达到 10 0 % ;而在较高浓度 (>17mmol/L)时 ,COD减少 ,COT含量增加 在不同的浓度区间 ,无论是COM含量减少 ,还是COT含量增加 ,或者是COD含量的先增加后减少 ,均与该羧酸钾浓度的对数呈线性关系 .不同羧酸钾抑制COM生长并诱导COD形成的能力顺序为 :K3cit>K2 edta >>K2 tart～KAc ,诱导COT生长的能力顺序为 :K2 tart>>K3cit>K2 edta >>KAc.由此推测抑制草酸钙结石形成的潜在效率依次为 :K3cit>K2 edta >>K2 tart>>The effects of different kinds of potassium carboxylates on the phase compositions of calcium oxalate (CaOxa) crystals grown in lecithin-water liposomes were first reported. The investigated potassium carboxylates included: monocarboxylate potassium acetate (KAc), dicarboxylate potassium tartrate (K(2)tart), tricarboxylate potassium citrate (K(3)cit), and tetracarboxylate dipotassium of ethylenediaminetetraacetic acid (K(2)edta). KAc only induces calcium oxalate monohydrate (COM). Calcium oxalate trihydrate (COT) was induced when concentrations of K(2)tart > 1.0 mmol/L. K(3)cit and K(2)edta can induce COM, calcium oxalate dihydrate (COD) and COT crystals depending on their concentrations. In a lower concentration range ( 1.0 similar to 17 mmol/L), the COM content decreased and the COD content increased with increasing concentration of the K(3)cit or K(2)edta in logarithmic fashion. In a medium concentration range (3.3 to 17 mmol/L), only COD was grown. In a higher concentration range ( > 17 mmol/L), COT was nucleated. The ability to induce COD follows the order: K(3)cit > K(2)edta > > K(2)tart similar to KAc, and the ability to induce COT follows: K(2)tart > > K(3)cit > K(2)edta > > KAc. Since the affinity of calcium oxalate hydrates to the membranes of renal tubule cells follows: COM > COT > COD, that is, COD is easily expelled from human body along with urine. So the inhibitory efficiency of potassium carboxylates on CaOxa stones can be deduced as K(3)cit > K(2)edta > > K(2)tart > > KAc.

关 键 词：脂质体 种类 羧酸钾 草酸钙 晶体生长 调控作用 生物矿化 尿结石 

分 类 号：O782[理学—晶体学] R694.4[医药卫生—泌尿科学]