绿色路易斯酸三卤化铟在有机合成中的应用  

Application of Green Lewis acid Catalyst──Indium Trihalide in Organic Synthesis

作　　者：傅南雁[1] 庞美丽[1] 袁耀锋[1] 王积涛[1] 

机构地区：[1]南开大学化学系,元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2003年第10期1085-1090,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金 (Nos.2 9872 0 1 8;2 9972 0 2 6);南开大学元素有机化学国家重点实验室和高教部博士点基金(No.1 9990 0 552 0 )资助项目

摘　　要：三卤化铟作为温和的路易斯酸可在水、醇等绿色溶剂中实现高化学选择性、高区域选择性和高立体选择性的化学转化 .综述了三卤化铟在羟醛反应和类羟醛 -曼尼希反应、Friedel Crafts反应、环氧化合物的重排反应、α 氨基膦酸的合成、喹啉环系的构建、酯交换反应、Diels Alder反应和杂Diels Alder反应、手性呋喃二醇的合成、水相中的叠氮解反应和二硫缩醛的制备中的应用 ,同时还总结了本课题组将三卤化铟应用于Biginelli反应和还原脱氧反应的反应结果 .三卤化铟在有机合成中潜在的优势将推动“绿色化学”的发展 .Indium trihalide is a mild green catalyst for organic synthesis in a highly chemo-, regio-, and stero-selectively fashion in green solvent such as aqueous and alcoholic media. In this paper, some applications of indium trihalide in organic synthesis are reviewed including aldol reaction, Friedel-Crafts reaction, the rearrangement of epoxides, the synthesis of alpha-aminophosphonates, the synthesis of quinolines, the transestenification, the hetero Diels-Alder reaction, the synthesis of chiral furan diols, the azidolysis in aqueous media and the dithioacetalization. At the same time, our works on the application of indium trihalide in Biginelli reaction and reductive deoxygenation reaction area are also dicussed. The potential superiority of indium trihalide in organic synthesis will promote the development of 'Green Chemistry'.

关 键 词：绿色化学 路易斯酸 催化 三卤化铟 有机合成 应用 

分 类 号：O621.3[理学—有机化学] O643.36[理学—化学]