C反应蛋白增高在心房颤动中的意义  

The significance of elevated C-reactive protein in patients with atrial fibrillation

作　　者：杜于茜[1] 郑文远[1] 卞福民[1] 

机构地区：[1]台州医院心内科,浙江台州317000

出　　处：《临床心血管病杂志》2003年第10期604-605,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨C反应蛋白 (CRP)增高在心房颤动 (房颤 )发病中的意义。方法 :应用免疫比浊法测定 96例诊断为房颤患者血清CRP水平 ,与对照组比较 ,并对房颤按持续时间、病因不同分设亚组 ,进行统计学分析。结果 :房颤组、对照组血清CRP水平分别为 (4 .30± 2 .87)、(1.15± 0 .90 )mg L ,两组相比P <0 .0 5。器质性、孤立性房颤者CRP水平分别为 (5 .0 6± 1.92 )、(4 .37± 1.32 )mg L ,均高于对照组 ,P <0 .0 5。持续性、永久性房颤者CRP水平分别为 (5 .6 0± 1.80 )、(5 .0 0± 1.6 0 )mg L ,均高于阵发性房颤 [(3.30± 1.2 0 )mg L],P <0 .0 5。结论 :CRP增高反映的炎症状态可能促进房颤发生 ,以及呈持续性发作。Objective:To evaluated the effect of CRP increasing in pathogenesis of atrial fibrillation.Methods:The immunochemistry method was used to determine the serum CRP concentration in 96 AF patients. Grouping these patients according to the lasting paroxysm of AF and pathogenetic factor.Results:Serum CRP level of patients with AF ( 4.3 ± 2.87 ) mg/L was higher than that in control group ( 1.15 ±0.90) mg/ml. P< 0.05 . The CRP level of isolated AF patients were ( 5.06 ± 1.92 ) and ( 4.37 ± 1.32 )mg/L, higher than that in control group respectively. P< 0.05 . serum CRP level of persistant and permanent AF patients were ( 5.60 ± 1.80 ), ( 5.00 ± 1.60 ) mg/L respectiocly higher than that in paroxysmal AF ( 3.30 ± 1.20 mg/ml P< 0.05 ).Conclusion:The inflannmatory state, reflected by the elevation of serum CRP level, may promote the occurence and persistence of AF.

关 键 词：心房颤动 C反应蛋白 

分 类 号：R541.7[医药卫生—心血管疾病]