甲状腺功能对地西泮及其代谢产物在大鼠体内代谢的影响  

Influence of thyroid function on metabolisms of diazepam and nordiazepa m in rats

作　　者：但汉雄[1] 

机构地区：[1]湖北药检高等专科学校药学系药理学教研室

出　　处：《中国临床药理学与治疗学》2003年第6期686-688,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :研究甲状腺功能对地西泮及其代谢物的药代动力学影响。方法 :采用HPLC技术 ,测定不同甲状腺功能状态时 ,大鼠血液中地西泮及其体内主要代谢产物去甲基地西泮的浓度。结果 :甲亢组大鼠地西泮在体内消除加速 ,峰浓度下降 ,AUC减少 ,消除T1 2 缩短。甲减组大鼠则消除减慢 ,峰浓度增高 ,AUC增大 ,消除T1 2 延长。而其主要代谢产物去甲地西泮的药动学参数则相反。结论 :甲状腺功能提高时 ,大鼠对地西泮的代谢能力明显增加 ,消除加速 ;AIM: To observe the influence of thyroid function on metabol is m of diazepam and nordiazepam in rats. METHODS: HPLC method was used to determine the blood concentrations of diazepam and nordiazepam from rats with different thyroid function. RESULTS: Diazepam was metaboli zed rapidly in the rats with hyperthyroidism, the Cmax and AUC were decreased, a nd the T 1/2 was cut short, but it showed an opposite resul ts in the rats with hypothyroidism. While pharmacokinetic parameters of diazepam were opposite in comparison with nordiazepam. CONCLUSION: Metab olism of diazepam increases in rats with hyperthyroidism.

关 键 词：药动学 甲状腺 地西泮 去甲地西泮 药物代谢 

分 类 号：R969.1[医药卫生—药理学]