口服阿奇霉素、米诺环素、氟罗沙星治疗男性非淋菌性尿道炎的成本-效果分析  

Cost-effectiveness analysis of three schemes in treatment of patients with nongonococcal urethritis

作　　者：李东[1] 王晓玲[1] 孙业红[1] 

机构地区：[1]暨南大学医学院第二附属医院,深圳市人民医院临床药学研究室,广东深圳518020

出　　处：《中国临床药理学与治疗学》2003年第6期692-695,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：深圳市卫生科技计划项目 (№ 2 0 0 0 0 60 18)

摘　　要：目的 :评价阿奇霉素与米诺环素、氟罗沙星口服治疗非淋菌性尿道炎的经济性 ,选择疗效佳、费用低的药物治疗方案。方法 :选择采用 3种不同药物治疗方案 (A组 :阿奇霉素po 0 .5gqd× 7首剂加倍 ;B组 :米诺环素po 10 0mg ,bid× 7;C组 :氟罗沙星po 0 .2g ,qd× 7)的非淋菌性尿道炎病例共 14 2例 ,运用药物经济学的成本 效果分析方法进行评价。结果 :3种方案的成本 效果比 (C E)分别为386 .4 3元、4 2 7.4 2元、395 .71元 ,总有效率分别为98.2 1%、75 .5 6 %、80 .4 9% (χ2 =12 .0 7,P <0 .0 1)。结论 :口服阿奇霉素成本 效果最佳 ;氟罗沙星市场价格偏高 ,建议厂商重新考虑中国市场的药品定价策略。AIM: To evaluate the cost-effectiveness of azithromycin, mi no cycline and fleroxacin in treatment of patients with nongonococcal urethritis. METHODS: 142 cases including A, B and C schemes were evaluated b y cost-effectiveness principle. A scheme: received azithromycin 0.5 g , po, qd×7, and the first dose doubled; B scheme: received minocyclin e 100 mg , po, bid×7; and C scheme: received fleroxacin 0. 2 g , po, qd×7. RESULTS: The cost of A, B and C schemes were RMB 386.43 , 427.42 and 395.71 yuan, respectively, an d the effective ratio were 98.21 %, 75.56 % and 80.49 % (χ 2= 12.07 , P< 0.01 ), respectively. CONCLUSION: A sc heme is the best one.

关 键 词：药效学 阿奇霉素 米诺环素 氟罗沙星 药物经济学 成本-效果分析 定价 非淋菌性尿道炎 

分 类 号：R969.3[医药卫生—药理学] R97[医药卫生—药学]