模拟脑肿瘤生长动态的细胞自动机研究  

SIMULATION OF BRAIN TUMOR GROWTH WITH A CELLULAR AUTOMATON

作　　者：阮晓钢[1] 胡日查[1] 

机构地区：[1]北京工业大学电子信息与控制工程学院,北京100022

出　　处：《中国生物医学工程学报》2003年第5期404-409,共6页Chinese Journal of Biomedical Engineering

基　　金：北京市自然科学基金资助项目 ( 3 993 0 10 )

摘　　要：文中构造了一种模拟GBM肿瘤生长动态的三维细胞自动机 (简称CASTG)。基于扩展Moore邻域 ,CASTG统一了肿瘤细胞中增殖细胞、非增殖细胞和坏死细胞的演化规则。CASTG的细胞及其邻域和演化规则完全遵循标准细胞自动机的设计原则 ,因而 ,易于在细胞自动机统一的理论框架下对其模拟肿瘤生长动态的能力或性能进行虚拟试验和分析。计算机仿真实验表明 ,CASTG模拟GBM肿瘤生长动态的结果与临床数据具有良好的一致性。This paper constructs a three-dimensional cellular automaton for simulating GBM tumor growth (CASTG). With extended Moore neighborhood, the CASTG unifies the rules for evolution of the proliferative cells, the non-proliferative cells and the necrotic cells. The cells and neighborhoods and rules of the CASTG completely abide the designed principle of standard cellular automata so that virtual experiment and analysis on the CASTG can be carried out under the unified theoretical frame of cellular automata. The results of simulating GBM tumor with the CASTG were consistent with the clinical data taken from the medical literature.

关 键 词：细胞自动机 肿瘤建模 随机生长模型 

分 类 号：R318[医药卫生—生物医学工程] TP301[医药卫生—基础医学]