肝硬化患者糖代谢异常及胰岛素抵抗的临床研究  

Clinical study of abnormal glucose metabolism and insulin resistance on liver cirrhosis patients

作　　者：毛志东[1] 

机构地区：[1]南京医科大学第三附属医院消化内科,江苏仪征211900

出　　处：《临床荟萃》2003年第18期1028-1029,共2页Clinical Focus

摘　　要：目的　探讨肝硬化糖代谢异常及胰岛素抵抗的病因和机制。方法　对 2 8例肝硬化患者 ,30例正常人进行了空腹血糖 (FPG)、餐后 2小时血糖 (PPG)、血清空腹胰岛素 (FINS)的检测 ,计算胰岛素释放指数 (IRI)及胰岛素敏感指数 (ISI) ,对各项结果进行比较分析。结果　肝硬化组存在着糖耐量异常 ,餐后 2小时血糖、血清空腹胰岛素、胰岛素释放指数显著高于正常对照组 (P <0 .0 1)。胰岛素敏感指数 ,显著低于正常对照组 (P <0 .0 1)。肝硬化Child分级比较 ,随着病情加重 ,糖代谢紊乱逐渐突出。结论　肝硬化失代偿患者存在糖代谢异常 ,这种代谢异常和肝功能损害。Objective To investigate the pathology and mechanism of abnormal glucose metabolism and insulin resistance on the liver cirrhosis patients. Methods Tests for fasting plasma glucose, postprandial glucose, fasting plasma insulin were performed in 30 liver cirrhosis patients and 30 controls.Insulin release index (IRI) and insulin sensitivity index (ISI) were calculated. Results Cirrhosis group showed hepatogenous glucose tolerance impairment, its postprandial glucose, fasting plasma insulin and IRI were significantly higher than that in controls(P< 0.01),ISI was markedly lower than controls(P< 0.01).Child-Pugh liver function classifications were compared in cirrhosis .With disease aggravated,the changes of glucose metabolism became heavier. Conclusion There is abnormal glucose metabolism on the liver cirrhosis patients.Insulin resistance and hepatonic dysfunction may play important roles in occurrence and development of hepatic abnormal glucose metabolism.

关 键 词：肝硬化 葡萄糖代谢 胰岛素抵抗 病因 

分 类 号：R657.31[医药卫生—外科学]