癫痫的PET受体显像  

Receptor imaging by PET in epilepsy

作　　者：侯敏[1] 刘永昌[2] 

机构地区：[1]复旦大学上海医学院华山医院核医学科上海200040 [2]复旦大学上海医学院华山医院核医学科

出　　处：《国外医学（放射医学核医学分册）》2003年第4期168-171,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：癫痫患者脑组织标本及癫痫动物模型研究发现,多种神经递质与癫痫有关。通过向体内引入这些神经递质不同受体亚型的特异性放射性配体,可以得到脑内受体分布图,反映它们在癫痫发生中的作用,同时检测出癫痫灶,这也就是癫痫的PET受体显像原理。较之于传统的癫痫检查方法,PET受体显像的特异性和敏感性都极高,可以检测出MRI、CT阴性的癫痫灶,具有很高的临床诊断价值,而且为研究癫痫的发病机制、抗痫药物及抗痫疗效评估提供了一种很好的无创伤性手段,从而为难治性癫痫的最终攻克带来希望。Alterations in a variety of neurotransmitter systems have been identified in experimental models of epilepsy and in brain tissue from patients with intractable temporal lobe seizures.The availability of new high-affinity radioligands per-mits the study of some neuroreceptors in vivo with positron emission tomography(PET).Receptor imaging by PET offers distinctive advantages over the more established imaging methods,including improved chemical specificity and improved sensitivity in detecting changes in disease.Development of new PET methods for the study of presynaptic and postsynaptic neurotransmitter functions will offer unique opportunities in the study of epileptic mechanisms and the way to assess the ef-fect of antiepilepstics,which will bring light on complete overcome of epilepsy.

关 键 词：癫痫 脑组织 标本 PET受体显像 动物模型 神经递质 MRI CT 

分 类 号：R817.4[医药卫生—影像医学与核医学]