白血病抑制因子在原发不孕症患者子宫内膜的表达  

Expression of Leukaemia Inhibitory Factor in Endometrial of the Patients with Unexplained Infertility

作　　者：张松灵[1] 张晓霞[1] 杨玉兰[1] 

机构地区：[1]吉林大学第一医院妇产科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2003年第5期643-644,657,共3页Journal of Jilin University：Medicine Edition

摘　　要：目的 :探讨白血病抑制因子 ( LIF)在子宫内膜的表达与原发不孕症的关系。方法 :采用逆转录聚合酶链反应 ( RT- PCR)技术 ,检测 30例原发不孕症患者 (观察组 )和 2 0例对照组患者分泌中晚期子宫内膜 LIF m RNA的表达。结果 :对照组患者分泌中晚期子宫内膜 LIF m RNA的表达水平为 1 .872± 0 .431 ,观察组为 0 .42 6± 0 .1 0 8,两组相比 ,差异有显著性 ( P<0 .0 0 1 )。结论 :LIF表达的减少或缺失 。Objective:To investigate the expression of leukaemia inhibitory factor (LIF) in endometrial of patients with unexplained infertility. Methods:By a quantitative reverse transcription polymerase chain reaction (RT PCR),the expression of LIF in endometrium during mid luteal phase in 30 cases infertility group (unexplained infertility) and 20 cases control group was detected. Results:The level of LIF mRNA expression on endometrium during mid luteal phase in infertility group was 0.426±0.108,significantly lower than those in the control group. Conclusion:The decreased expression of LIF may be one of the major causes of unexplained infertility. [

关 键 词：子宫内膜 生理学 白血病抑制因子 卵植入 女(雌)性不育 病因学 逆转录聚合酶链反应 

分 类 号：R711.6[医药卫生—妇产科学]